Contraindications/Black Box Warnings - Antivirals

Question 1

Acyclovir contraindications

Answer 1

Hypersensitivity to acyclovir or valacyclovir

Question 2

Atazanavir contraindications

Answer 2

Hypersensitivity or concurrent therapy with interacting medications

Question 3

Elbasivir/Grazoprevir contraindications

Answer 3

Hepatic impairment, strong CYP3A4/5 inducers

Question 4

Efavirenz contraindications

Answer 4

Hypersensitivity or concurrent use of bepridil, cisapride, elbasvir, grazoprevir, midazolam, pimozide, triazolam, St. John’s wort, or ergot alkaloids

Question 5

Emtricitabine/Tenofovir contraindications

Answer 5

Do not use for preexposure prophylaxis in patients with unknown or HIV-1 positive status. Only for use in combination with other antiretrovirals

Question 6

Entecavir contraindications

Answer 6

None

Question 7

Glecaprevir/Pibrentasvir contraindications

Answer 7

Hepatic impairment, concomitant use with atazanavir and rifampin

Question 8

Maraviroc contraindications

Answer 8

Patients with CrCL < 30 mL/min or ESRD who are taking potent CYP3A4/5 inhibitors or inducers

Question 9

Oseltamivir contraindications

Answer 9

Hypersensitivity to oseltamivir

Question 10

Raltegravir contraindications

Answer 10

Hypersensitivity to raltegravir

Question 11

Sofosbuvir contraindications

Answer 11

Because of ribavirin risk, do not use in pregnant women, or men whose female partners are pregnant

Question 12

Valacyclovir contraindications

Answer 12

Hypersensitivity

Question 13

Elbasivir/Grazoprevir BBW

Answer 13

HBV reactivation

Question 14

Emtricitabine/Tenofovir BBW

Answer 14

Hepatitis B exacerbation, lactic acidosis, drug resistance with preexposure prophylaxis

Question 15

Entecavir BBW

Answer 15

HIV resistance in chronic hepatitis B patients with unrecognized or untreated HIV infection; discontinuation of therapy may result in disease exacerbation; lactic acidosis

Question 16

Glecaprevir/Pibrentasvir BBW

Answer 16

HBV reactivation

Question 17

Maraviroc BBW

Answer 17

Hepatotoxicity, severe rash, allergic reaction

Question 18

Sofosbuvir BBW

Answer 18

HBV reactivation