Common and Rare/Severe AE - Pain/GU Flashcards
Baclofen common ADRs
Nausea, asthenia, dizziness, somnolence, confusion
Baclofen Rare but serious ADRs
Slowed or difficult breathing when used in combination with opioids, pneumonia, GI hemorrhage, seizure.
Buprenorphine/Naloxone common ADRs
Vasodilation, sweating, headaches, insomnia, constipation, GI distress, opioid withdrawal, dizziness
Buprenorphine/Naloxone Rare but serious ADRs:
Stevens-Johnson syndrome, physical dependence, tolerance, elevated liver functions tests, seizures.
Carisoprodol common ADRs
Drowsiness, dizziness
Carisoprodol Rare but serious ADRs:
Slowed or difficult breathing when used in combination with opioids, seizure, drug dependence, withdrawal symptoms upon discontinuation after chronic use.
Celecoxib common ADRs
HTN, headaches, GI distress, diarrhea
Celecoxib Rare but serious ADRs:
Stevens-Johnson syndrome, GI ulcers and bleeding, thrombosis, elevated liver functions, acute renal failure.
Codeine/Acetaminophen common ADRs
Nausea, vomiting, constipation, somnolence
Codeine/Acetaminophen Rare but serious ADRs:
Stevens-Johnson syndrome, GI bleeding, elevated liver functions, thrombocytopenia, physical dependence, tolerance, respiratory depression, serotonin syndrome, adrenal insufficiency, decreased sex hormones.
Cyclobenzaprine common ADRs
Xerostomia, headache, dizziness, drowsiness
Cyclobenzaprine Rare but serious ADRs:
Cardiac dysrhythmia, cholestasis, hepatitis, jaundice, anaphylaxis, immune hypersensitivity reaction, slowed or difficult breathing when used in combination with opioids.
Diclofenac common ADRs
Headaches, GI distress
Diclofenac Rare but serious ADRs:
Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated liver functions, acute renal failure, MI, aplastic anemia, hemolytic anemia.
Etodolac common ADRs
None known
Etodolac Rare but serious ADRs:
Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated liver functions, acute renal failure, congestive heart failure, aplastic anemia.
Fentanyl Transdermal common ADRs
Application site reactions, sweating, constipation, GI distress, confusion, headache, anxiety, urinary retention, fatigue
Fentanyl Transdermal Rare but serious ADRs:
Stevens-Johnson syndrome, physical dependence, tolerance.
Hydrocodone (w/o acetaminophen) common ADRs
Constipation, GI distress, somnolence
Hydrocodone (w/o acetaminophen) Rare but serious ADRs:
Stevens-Johnson syndrome, physical dependence, tolerance, respiratory depression, serotonin syndrome, adrenal insufficiency, decreased sex hormones.
Ibuprofen common ADRs
None known
Ibuprofen Rare but serious ADRs:
Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated liver functions, acute renal failure, congestive heart failure, aplastic anemia.
Indomethacin common ADRs
Headache
Indomethacin Rare but serious ADRs:
Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated LFTs, acute renal failure, heart failure, aplastic anemia.
Lidocaine common ADRs
Skin irritation, somnolence
Lidocaine Rare but serious ADRs:
Cardiac arrest, cardiac dysrhythmia, seizure, methemoglobinemia.
Meloxicam common ADRs
GI Distress
Meloxicam Rare but serious ADRs:
Stevens-Johnson syndrome, GI bleeding, elevated LFT, acute renal failure, congestive heart failure, aplastic anemia.
Methadone common ADRs
Constipation, GI distress, hypotension, dizziness, sedation
Methadone Rare but serious ADRs:
Respiratory depression, arrhythmias, Stevens-Johnson syndrome, QTc prolongation, serotonin syndrome, adrenal insufficiency, hypogonadism.
Methocarbamol common ADRs
Somnolence
Methocarbamol Rare but serious ADRs:
Bradyarrhythmia, hypotension, syncope, leukopenia, anaphylactoid reaction, slowed or difficult breathing when used in combination with opioids.
Morphine common ADRs
Constipation, nausea, vomiting, hypotension, dizziness, sedation, diaphoresis, headaches, depression, xerostomia
Morphine Rare but serious ADRs:
Cardiac arrest, physical dependence, respiratory depression, serotonin syndrome, adrenal insufficiency, decreased sex hormones.
Nabumetone common ADRs
Elevated LFTs, dyspepsia, abdominal pain, diarrhea
Nabumetone Rare but serious ADRs:
Stevens-Johnson syndrome, GI bleeding, thrombosis, acute renal failure, congestive heart failure, aplastic anemia.
Naproxen common ADRs
None known
Naproxen Rare but serious ADRs:
Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated LFTs, acute renal failure, congestive heart failure, aplastic anemia.
Oxycodone common ADRs
Constipation, GI distress, sedation, sweating, pruritus
Oxycodone Rare but serious ADRs:
Cardiac arrest, respiratory depression, physical dependence, tolerance, severe hypersensitivity, serotonin syndrome, adrenal insufficiency, decreased sex hormones.
Pentosan common ADRs
Nausea
Pentosan Rare but serious ADRs:
Rectal hemorrhage, proctitis, thrombocytopenia.
Tramadol common ADRs
Constipation, GI distress, dizziness, sedation, edema, sweating, pruritus, headaches, flushing
Tramadol Rare but serious ADRs:
Cardiac arrest, physical dependence, tolerance, seizures, pancreatitis, suicidal ideation, anemia, serotonin syndrome, adrenal insufficiency, decreased sex hormones.
Tizanidine common ADRs
Hypotension, xerostomia, asthenia, dizziness, somnolence, muscle weakness
Tizanidine Rare but serious ADRs:
AMI, thrombocytopenia, hepatitis, PE, hypersensitivity, death, slowed or difficult breathing when used in combination with opioids.
Darifenacin common ADRs
Constipation, xerostomia, blurred vision
Darifenacin Rare but serious ADRs:
Angioedema.
Dutasteride common ADRs
None known
Dutasteride Rare but serious ADRs:
Heart failure, angioedema, allergic skin reactions, male breast cancer, prostate cancer (high grade).
Finasteride common ADRs
Impotence, reduced libido
Finasteride Rare but serious ADRs:
Heart failure, angioedema, allergic skin reactions, male breast cancer, prostate cancer (high grade).
Mirabegron common ADRs
Hypertension
Mirabegron Rare but serious ADRs:
Atrial fibrillation, angioedema, hallucinations, increased liver function enzymes.
Oxybutynin common ADRs
Constipation, xerostomia, blurred vision
Oxybutynin Rare but serious ADRs:
Prolonged QTc interval, seizures, tachycardia.
Sildenafil common ADRs
Flushing, nausea, headache, visual disturbances, lack of blue/green color discrimination
Sildenafil Rare but serious ADRs:
AMI, seizures, strokes, sudden hearing loss, priapism.
Solifenacin common ADRs
Constipation, xerostomia, blurred vision
Solifenacin Rare but serious ADRs:
Angioedema, QTc prolongation, exfoliative dermatitis.
Tadalafil common ADRs
Flushing, nausea, myalgia, headache
Tadalafil Rare but serious ADRs:
Stevens-Johnson syndrome, AMI, seizures, strokes, sudden hearing loss.
Tamsulosin common ADRs
Dizziness, headache, abnormal ejaculation, rhinitis
Rare but serious ADRs: Retinal detachment, priapism.
Tamsulosin Rare but serious ADRs:
Retinal detachment, priapism.
Tolterodine common ADRs
Xerostomia
Tolterodine Rare but serious ADRs:
Tachycardia, QTc prolongation, angioedema, hallucinations.
Vardenafil common ADRs
Flushing, headache
Vardenafil Rare but serious ADRs:
Acute myocardial infarction (AMI), seizures, strokes, sudden hearing loss, priapism, nonarteritic anterior ischemic optic neuropathy (NAION).
Phenazopyridine common ADRs
GI upset
Phenazopyridine Rare but serious ADRs:
Anaphylaxis, methemoglobinemia, hemolytic anemia, hepatotoxic, nephrotoxicity.