Common and Rare/Severe AE - Pain/GU

Question 1

Baclofen common ADRs

Answer 1

Nausea, asthenia, dizziness, somnolence, confusion

Question 2

Baclofen Rare but serious ADRs

Answer 2

Slowed or difficult breathing when used in combination with opioids, pneumonia, GI hemorrhage, seizure.

Question 3

Buprenorphine/Naloxone common ADRs

Answer 3

Vasodilation, sweating, headaches, insomnia, constipation, GI distress, opioid withdrawal, dizziness

Question 4

Buprenorphine/Naloxone Rare but serious ADRs:

Answer 4

Stevens-Johnson syndrome, physical dependence, tolerance, elevated liver functions tests, seizures.

Question 5

Carisoprodol common ADRs

Answer 5

Drowsiness, dizziness

Question 6

Carisoprodol Rare but serious ADRs:

Answer 6

Slowed or difficult breathing when used in combination with opioids, seizure, drug dependence, withdrawal symptoms upon discontinuation after chronic use.

Question 7

Celecoxib common ADRs

Answer 7

HTN, headaches, GI distress, diarrhea

Question 8

Celecoxib Rare but serious ADRs:

Answer 8

Stevens-Johnson syndrome, GI ulcers and bleeding, thrombosis, elevated liver functions, acute renal failure.

Question 9

Codeine/Acetaminophen common ADRs

Answer 9

Nausea, vomiting, constipation, somnolence

Question 10

Codeine/Acetaminophen Rare but serious ADRs:

Answer 10

Stevens-Johnson syndrome, GI bleeding, elevated liver functions, thrombocytopenia, physical dependence, tolerance, respiratory depression, serotonin syndrome, adrenal insufficiency, decreased sex hormones.

Question 11

Cyclobenzaprine common ADRs

Answer 11

Xerostomia, headache, dizziness, drowsiness

Question 12

Cyclobenzaprine Rare but serious ADRs:

Answer 12

Cardiac dysrhythmia, cholestasis, hepatitis, jaundice, anaphylaxis, immune hypersensitivity reaction, slowed or difficult breathing when used in combination with opioids.

Question 13

Diclofenac common ADRs

Answer 13

Headaches, GI distress

Question 14

Diclofenac Rare but serious ADRs:

Answer 14

Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated liver functions, acute renal failure, MI, aplastic anemia, hemolytic anemia.

Question 15

Etodolac common ADRs

Answer 15

None known

Question 16

Etodolac Rare but serious ADRs:

Answer 16

Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated liver functions, acute renal failure, congestive heart failure, aplastic anemia.

Question 17

Fentanyl Transdermal common ADRs

Answer 17

Application site reactions, sweating, constipation, GI distress, confusion, headache, anxiety, urinary retention, fatigue

Question 18

Fentanyl Transdermal Rare but serious ADRs:

Answer 18

Stevens-Johnson syndrome, physical dependence, tolerance.

Question 19

Hydrocodone (w/o acetaminophen) common ADRs

Answer 19

Constipation, GI distress, somnolence

Question 20

Hydrocodone (w/o acetaminophen) Rare but serious ADRs:

Answer 20

Stevens-Johnson syndrome, physical dependence, tolerance, respiratory depression, serotonin syndrome, adrenal insufficiency, decreased sex hormones.

Question 21

Ibuprofen common ADRs

Answer 21

None known

Question 22

Ibuprofen Rare but serious ADRs:

Answer 22

Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated liver functions, acute renal failure, congestive heart failure, aplastic anemia.

Question 23

Indomethacin common ADRs

Answer 23

Headache

Question 24

Indomethacin Rare but serious ADRs:

Answer 24

Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated LFTs, acute renal failure, heart failure, aplastic anemia.

Question 25

Lidocaine common ADRs

Answer 25

Skin irritation, somnolence

Question 26

Lidocaine Rare but serious ADRs:

Answer 26

Cardiac arrest, cardiac dysrhythmia, seizure, methemoglobinemia.

Question 27

Meloxicam common ADRs

Answer 27

GI Distress

Question 28

Meloxicam Rare but serious ADRs:

Answer 28

Stevens-Johnson syndrome, GI bleeding, elevated LFT, acute renal failure, congestive heart failure, aplastic anemia.

Question 29

Methadone common ADRs

Answer 29

Constipation, GI distress, hypotension, dizziness, sedation

Question 30

Methadone Rare but serious ADRs:

Answer 30

Respiratory depression, arrhythmias, Stevens-Johnson syndrome, QTc prolongation, serotonin syndrome, adrenal insufficiency, hypogonadism.

Question 31

Methocarbamol common ADRs

Answer 31

Somnolence

Question 32

Methocarbamol Rare but serious ADRs:

Answer 32

Bradyarrhythmia, hypotension, syncope, leukopenia, anaphylactoid reaction, slowed or difficult breathing when used in combination with opioids.

Question 33

Morphine common ADRs

Answer 33

Constipation, nausea, vomiting, hypotension, dizziness, sedation, diaphoresis, headaches, depression, xerostomia

Question 34

Morphine Rare but serious ADRs:

Answer 34

Cardiac arrest, physical dependence, respiratory depression, serotonin syndrome, adrenal insufficiency, decreased sex hormones.

Question 35

Nabumetone common ADRs

Answer 35

Elevated LFTs, dyspepsia, abdominal pain, diarrhea

Question 36

Nabumetone Rare but serious ADRs:

Answer 36

Stevens-Johnson syndrome, GI bleeding, thrombosis, acute renal failure, congestive heart failure, aplastic anemia.

Question 37

Naproxen common ADRs

Answer 37

None known

Question 38

Naproxen Rare but serious ADRs:

Answer 38

Stevens-Johnson syndrome, GI bleeding, thrombosis, elevated LFTs, acute renal failure, congestive heart failure, aplastic anemia.

Question 39

Oxycodone common ADRs

Answer 39

Constipation, GI distress, sedation, sweating, pruritus

Question 40

Oxycodone Rare but serious ADRs:

Answer 40

Cardiac arrest, respiratory depression, physical dependence, tolerance, severe hypersensitivity, serotonin syndrome, adrenal insufficiency, decreased sex hormones.

Question 41

Pentosan common ADRs

Answer 41

Nausea

Question 42

Pentosan Rare but serious ADRs:

Answer 42

Rectal hemorrhage, proctitis, thrombocytopenia.

Question 43

Tramadol common ADRs

Answer 43

Constipation, GI distress, dizziness, sedation, edema, sweating, pruritus, headaches, flushing

Question 44

Tramadol Rare but serious ADRs:

Answer 44

Cardiac arrest, physical dependence, tolerance, seizures, pancreatitis, suicidal ideation, anemia, serotonin syndrome, adrenal insufficiency, decreased sex hormones.

Question 45

Tizanidine common ADRs

Answer 45

Hypotension, xerostomia, asthenia, dizziness, somnolence, muscle weakness

Question 46

Tizanidine Rare but serious ADRs:

Answer 46

AMI, thrombocytopenia, hepatitis, PE, hypersensitivity, death, slowed or difficult breathing when used in combination with opioids.

Question 47

Darifenacin common ADRs

Answer 47

Constipation, xerostomia, blurred vision

Question 48

Darifenacin Rare but serious ADRs:

Answer 48

Angioedema.

Question 49

Dutasteride common ADRs

Answer 49

None known

Question 50

Dutasteride Rare but serious ADRs:

Answer 50

Heart failure, angioedema, allergic skin reactions, male breast cancer, prostate cancer (high grade).

Question 51

Finasteride common ADRs

Answer 51

Impotence, reduced libido

Question 52

Finasteride Rare but serious ADRs:

Answer 52

Heart failure, angioedema, allergic skin reactions, male breast cancer, prostate cancer (high grade).

Question 53

Mirabegron common ADRs

Answer 53

Hypertension

Question 54

Mirabegron Rare but serious ADRs:

Answer 54

Atrial fibrillation, angioedema, hallucinations, increased liver function enzymes.

Question 55

Oxybutynin common ADRs

Answer 55

Constipation, xerostomia, blurred vision

Question 56

Oxybutynin Rare but serious ADRs:

Answer 56

Prolonged QTc interval, seizures, tachycardia.

Question 57

Sildenafil common ADRs

Answer 57

Flushing, nausea, headache, visual disturbances, lack of blue/green color discrimination

Question 58

Sildenafil Rare but serious ADRs:

Answer 58

AMI, seizures, strokes, sudden hearing loss, priapism.

Question 59

Solifenacin common ADRs

Answer 59

Constipation, xerostomia, blurred vision

Question 60

Solifenacin Rare but serious ADRs:

Answer 60

Angioedema, QTc prolongation, exfoliative dermatitis.

Question 61

Tadalafil common ADRs

Answer 61

Flushing, nausea, myalgia, headache

Question 62

Tadalafil Rare but serious ADRs:

Answer 62

Stevens-Johnson syndrome, AMI, seizures, strokes, sudden hearing loss.

Question 63

Tamsulosin common ADRs

Answer 63

Dizziness, headache, abnormal ejaculation, rhinitis ## Footnote Rare but serious ADRs: Retinal detachment, priapism.

Question 64

Tamsulosin Rare but serious ADRs:

Answer 64

Retinal detachment, priapism.

Question 65

Tolterodine common ADRs

Answer 65

Xerostomia

Question 66

Tolterodine Rare but serious ADRs:

Answer 66

Tachycardia, QTc prolongation, angioedema, hallucinations.

Question 67

Vardenafil common ADRs

Answer 67

Flushing, headache

Question 68

Vardenafil Rare but serious ADRs:

Answer 68

Acute myocardial infarction (AMI), seizures, strokes, sudden hearing loss, priapism, nonarteritic anterior ischemic optic neuropathy (NAION).

Question 69

Phenazopyridine common ADRs

Answer 69

GI upset

Question 70

Phenazopyridine Rare but serious ADRs:

Answer 70

Anaphylaxis, methemoglobinemia, hemolytic anemia, hepatotoxic, nephrotoxicity.