Contraindications/Black Box Warnings - Antibiotics/Antifungals

Question 1

Amoxicillin

Answer 1

Hypersensitivity

Question 2

Amoxicillin/Clavulanate

Answer 2

Hypersensitivity to penicillins; extended-release products are contraindicated in patients on dialysis or severe renal dysfunction, history of cholestatic jaundice or hepatic dysfunction with amoxicillin/clavulanate therapy

Question 3

Cefdinir

Answer 3

Hypersensitivity to cephalosporins

Question 4

Cefuroxime

Answer 4

Hypersensitivity to cephalosporins

Question 5

Cephalexin

Answer 5

Hypersensitivity to cephalosporins

Question 6

Chlorhexidine

Answer 6

Hypersensitivity to chlorhexidine

Question 7

Ciprofloxacin Oral

Answer 7

Hypersensitivity to quinolones, concomitant tizanidine; Black box: Serious adverse effects (tendon rupture, peripheral neuropathy, CNS), exacerbation of myasthenia gravis

Question 8

Ciprofloxacin Otic

Answer 8

Hypersensitivity to quinolones

Question 9

Clarithromycin

Answer 9

Hypersensitivity to any macrolide or ketolide antibiotic; concomitant colchicine, cisapride, pimozide, astemizole, terfenadine, ergotamine, dihydroergotamine, or HMG-CoA reductase inhibitors metabolized by CYP3A4/5, history of cholestatic jaundice/hepatic dysfunction with use of clarithromycin, colchicine in renal or hepatic impairment

Question 10

Clindamycin Oral

Answer 10

Hypersensitivity

Question 11

Doxycycline

Answer 11

Hypersensitivity to concurrent retinoic acid derivatives

Question 12

Erythromycin

Answer 12

Hypersensitivity, concurrent ergotamine, terfenadine, astemizole, lovastatin, simvastatin, cisapride

Question 13

Fidaxomicin

Answer 13

None

Question 14

Levofloxacin

Answer 14

Hypersensitivity to quinolones; concomitant tizanidine; Black box: Myasthenia gravis, tendon inflammation and rupture, peripheral neuropathy, CNS effects, cardiac, dermatologic and hypersensitivity reactions, aortic dissections and ruptures

Question 15

Metronidazole

Answer 15

Hypersensitivity, 1st trimester of pregnancy; Black Box: Carcinogenic

Question 16

Minocycline

Answer 16

Hypersensitivity

Question 17

Moxifloxacin (Oral/Ophthalmic)

Answer 17

Hypersensitivity; Black box: Myasthenia gravis, tendon inflammation and rupture peripheral neuropathy, aortic dissections, hypoglycemia, delirium

Question 18

Mupirocin

Answer 18

Hypersensitivity

Question 19

Nitrofurantoin

Answer 19

Hypersensitivity, use in neonates or pregnant patients at term (38-42 weeks) due to risk of hemolytic anemia, anuria, or oliguria

Question 20

Penicillin

Answer 20

Hypersensitivity

Question 21

Trimethoprim/Sulfamethoxazole

Answer 21

Hypersensitivity to sulfonamides, children <2 mo, pregnant patients at term, megaloblastic anemia due to folate deficiency, history of drug-induced thrombocytopenia with use of sulfonamides or trimethoprim, marked hepatic damage or severe renal disease, concomitant administration with dofetilide

Question 22

Azithromycin

Answer 22

Hypersensitivity to any macrolide or ketolide antibiotic

Question 23

Gatifloxacin Ophthalmic

Answer 23

Hypersensitivity to quinolones

Question 24

Fluconazole

Answer 24

Hypersensitivity, concurrent ergot alkaloids, CYP3A4/5 substrates that prolong QTc

Question 25

Ketoconazole Topical

Answer 25

Hypersensitivity

Question 26

Nystatin Systemic

Answer 26

Hypersensitivity

Question 27

Nystatin Topical

Answer 27

Hypersensitivity

Question 28

Terbinafine

Answer 28

Hypersensitivity