Common and Rare/Severe AE - Antibiotics/Antifungals

Question 2

Amoxicillin Common ADRs

Answer 2

Diarrhea, nausea

Question 3

Amoxicillin Rare but Serious ADRs

Answer 3

Severe hypersensitivity, renal failure, hepatic failure, pancytopenia

Question 4

Amoxicillin/Clavulanate Common ADRs

Answer 4

Nausea, diarrhea

Question 5

Amoxicillin/Clavulanate Rare but Serious ADRs

Answer 5

Severe hypersensitivity, renal failure, hepatic failure, pancytopenia

Question 6

Cefdinir Common ADRs

Answer 6

Diarrhea

Question 7

Cefdinir Rare but Serious ADRs

Answer 7

Increased liver enzymes, hypersensitivity

Question 8

Cefuroxime Common ADRs

Answer 8

Diarrhea

Question 9

Cefuroxime Rare but Serious ADRs

Answer 9

Stevens-Johnson syndrome, hepatotoxicity, severe hypersensitivity, anemia, neutropenia, pancytopenia, seizure

Question 10

Cephalexin Common ADRs

Answer 10

Nausea

Question 11

Cephalexin Rare but Serious ADRs

Answer 11

Stevens-Johnson syndrome, renal failure, severe hypersensitivity, anemia, neutropenia, seizure

Question 12

Chlorhexidine Common ADRs

Answer 12

Mouth irritation, tongue irritation, tooth aches, and discolored teeth with oral rinse

Question 13

Chlorhexidine Rare but Serious ADRs

Answer 13

Allergic reactions, skin irritation

Question 14

Ciprofloxacin Oral Common ADRs

Answer 14

Tooth discoloration in infants, musculoskeletal signs and symptoms

Question 15

Ciprofloxacin Oral Rare but Serious ADRs

Answer 15

Stevens-Johnson syndrome, renal failure, anemia, neutropenia, thrombocytopenia, seizure, cardiac effects, liver failure, myasthenia gravis, tendon rupture, renal failure, psychosis, QTc prolongation, peripheral neuropathy, CNS effects, severe cardiac, dermatologic, and hypersensitivity reactions

Question 16

Ciprofloxacin Otic Common ADRs

Answer 16

Application site pain and itching

Question 17

Ciprofloxacin Otic Rare but Serious ADRs

Answer 17

Hypersensitivity reactions

Question 18

Clarithromycin Common ADRs

Answer 18

Taste disturbance

Question 19

Clarithromycin Rare but Serious ADRs

Answer 19

QTc prolongation, Stevens-Johnson syndrome, anemia, neutropenia, thrombocytopenia, severe hypersensitivity, myasthenic crisis, elevated LFTs, hallucinations, nephrotoxicity

Question 20

Clindamycin Oral Common ADRs

Answer 20

Nausea

Question 21

Clindamycin Oral Rare but Serious ADRs

Answer 21

QTc prolongation, Stevens-Johnson syndrome, pseudomembranous colitis, esophagitis

Question 22

Doxycycline Common ADRs

Answer 22

Esophageal injury, photosensitivity, skin hyperpigmentation, tooth discoloration in children < 8 years of age

Question 23

Doxycycline Rare but Serious ADRs

Answer 23

Esophageal ulceration, hypersensitivity, hepatotoxicity, renal toxicity, C. difficile colitis, increased intracranial pressure, decreased growth in children

Question 24

Erythromycin Common ADRs

Answer 24

Diarrhea

Question 25

Erythromycin Rare but Serious ADRs

Answer 25

QTc prolongation, arrhythmias, Stevens-Johnson syndrome, hepatotoxicity, severe hypersensitivity, anemia, neutropenia, pancytopenia, seizure

Question 26

Fidaxomicin Common ADRs

Answer 26

Nausea

Question 27

Fidaxomicin Rare but Serious ADRs

Answer 27

Bowel obstruction, GI hemorrhage

Question 28

Levofloxacin Common ADRs

Answer 28

Photosensitivity

Question 29

Levofloxacin Rare but Serious ADRs

Answer 29

Stevens-Johnson syndrome, renal failure, severe hypersensitivity, anemia, neutropenia, thrombocytopenia, seizure, cardiac arrest, cardiac arrhythmias, liver failure, tendon rupture, psychosis, glucose abnormalities, C. difficile colitis, peripheral neuropathy, CNS effects, severe cardiac, dermatologic and hypersensitivity reactions

Question 30

Metronidazole Common ADRs

Answer 30

Headaches, nausea

Question 31

Metronidazole Rare but Serious ADRs

Answer 31

Severe hypersensitivity, seizures, ototoxicity, clinically insignificant dark urine, Stevens-Johnson syndrome, neutropenia/thrombocytopenia

Question 32

Minocycline Common ADRs

Answer 32

Dizziness and vertigo, tooth discoloration in children <8 y of age, headache

Question 33

Minocycline Rare but Serious ADRs

Answer 33

Hypersensitivity, hepatotoxicity, renal toxicity, C. difficile colitis, increased intracranial pressure, decreased growth in children, tissue hyperpigmentation

Question 34

Moxifloxacin (Oral/Ophthalmic) Common ADRs

Answer 34

None known

Question 35

Moxifloxacin (Oral/Ophthalmic) Rare but Serious ADRs

Answer 35

Stevens-Johnson syndrome, renal failure, severe hypersensitivity, anemia, neutropenia, thrombocytopenia, seizure, cardiac arrhythmias, liver failure, tendon rupture, psychosis, exacerbation of myasthenia gravis, peripheral neuropathy, CNS effects, severe cardiac, dermatologic and hypersensitivity reactions

Question 36

Mupirocin Common ADRs

Answer 36

None known

Question 37

Mupirocin Rare but Serious ADRs

Answer 37

C. difficile diarrhea

Question 38

Nitrofurantoin Common ADRs

Answer 38

Discoloration of urine

Question 39

Nitrofurantoin Rare but Serious ADRs

Answer 39

Severe hypersensitivity, hepatic failure, hemolytic anemia, interstitial lung disease

Question 40

Penicillin Common ADRs

Answer 40

Diarrhea, nausea, vomiting, oral candidiasis

Question 41

Penicillin Rare but Serious ADRs

Answer 41

Severe hypersensitivity, renal failure, hepatic failure, hemolytic anemia

Question 42

Trimethoprim/Sulfamethoxazole Common ADRs

Answer 42

Diarrhea, nausea

Question 43

Trimethoprim/Sulfamethoxazole Rare but Serious ADRs

Answer 43

Severe hypersensitivity, renal failure, hepatic failure, pancytopenia, arrhythmias, Stevens-Johnson syndrome, hyperkalemia, hypoglycemia, hemolytic anemia

Question 44

Azithromycin Common ADRs

Answer 44

Diarrhea, nausea, vomiting

Question 45

Azithromycin Rare but Serious ADRs

Answer 45

Stevens-Johnson syndrome, chest pain, severe hypersensitivity, myasthenia gravis, QTc prolongation, torsades de pointes, hepatitis

Question 46

Gatifloxacin Ophthalmic Common ADRs

Answer 46

None known

Question 47

Gatifloxacin Ophthalmic Rare but Serious ADRs

Answer 47

Conjunctival hemorrhage

Question 48

Fluconazole Common ADRs

Answer 48

Headache

Question 49

Fluconazole Rare but Serious ADRs

Answer 49

Stevens-Johnson syndrome, arrhythmias (prolonged QTc interval), adrenal suppression, agranulocytosis, seizures, elevated LFTs, hypokalemia

Question 50

Ketoconazole Topical Common ADRs

Answer 50

Application site reaction with foam

Question 51

Ketoconazole Topical Rare but Serious ADRs

Answer 51

Rash, hair loss

Question 52

Nystatin Systemic Common ADRs

Answer 52

None known

Question 53

Nystatin Systemic Rare but Serious ADRs

Answer 53

Rash

Question 54

Nystatin Topical Common ADRs

Answer 54

None known

Question 55

Nystatin Topical Rare but Serious ADRs

Answer 55

Rash, hypersensitivity reaction, Stevens-Johnson syndrome

Question 56

Terbinafine Common ADRs

Answer 56

None known

Question 57

Terbinafine Rare but Serious ADRs

Answer 57

None known