Common and Rare/Severe AE - Antivirals Flashcards
Acyclovir
Malaise; Severe hypersensitivity, renal failure, TTP
Atazanavir
Rash, hyperlipidemia, elevated LFTs, abdominal pain, elevated bilirubin level, cough, fever; Hypersensitivity, renal failure, PR and QTc prolongation, torsades de pointes, cholelithiasis, left bundle branch block
Elbasivir/Grazoprevir
Fatigue; Severe hepatic disease, anemia, angioedema
Efavirenz
Anxiety, dizziness, insomnia, headaches, rash, nausea, vomiting, diarrhea, hyperlipidemia; Psychosis, seizures, hepatic failure, hypersensitivity, pancreatitis, suicidal ideation, fat redistribution, immune reconstitution syndrome
Emtricitabine/Tenofovir
Hyperpigmentation, rash, hypophosphatemia, nausea, diarrhea, abdominal pain, weakness, cough, rhinitis, dizziness, headache, insomnia, fatigue, decreased bone mineral density; Lactic acidosis, HBV exacerbations, renal failure
Entecavir
Edema, elevated LFTs; Hypersensitivity, renal failure, hepatomegaly, thrombocytopenia
Glecaprevir/Pibrentasvir
Fatigue, nausea; Severe hepatic disease, angioedema
Maraviroc
Fever, URI, rash, cough, vomiting; Coronary artery disease, angina, jaundice, hepatic failure, seizures
Oseltamivir
Nausea, vomiting, headache; Arrhythmias, anaphylaxis, Stevens-Johnson syndrome, seizures, delirium
Raltegravir
Elevated LFTs; Anemia, cerebellar ataxia, depression, hepatitis, hypersensitivity, myopathy, nephrolithiasis, psychomotor hyperactivity (children), renal failure, rhabdomyolysis, Stevens-Johnson syndrome, suicidal ideation/behavior, thrombocytopenia, toxic epidermal necrolysis
Sofosbuvir
Fatigue, headache, insomnia, chills, pruritus, rash, nausea, anemia; Pancytopenia, depression, suicidality
Valacyclovir
Malaise, headache, nausea, neutropenia, nasopharyngitis, increased LFTs; Severe hypersensitivity, renal failure, TTP
