Connective Tissue Diseases Flashcards
Give some general symptoms of autoimmune diseases
Fatigue
Arthritis
Myalgia
Mucosal ulcers
Give some examples of connective tissue diseases
SLE Antiphospholipid syndrome Sjogren's Polymyositis Systemic sclerosis Mixed connective tissue disease
What is the main antibody involved in antiphospholipid syndrome?
Antibodies to phospholipid binding proteins
What is involved in antiphospholipid syndrome?
Venous or arterial thrombosis with adverse pregnancy outcomes
How is APS treated?
Lifelong anticoagulation
Aspirin
Hydroxycholoroquine
What is Sjogren’s syndrome?
A chronic autoimmune inflammatory disorder with diminished lacrimal and salivary gland function
What are the main clinical features of Sjogren’s?
Dry eyes, mouth, throat and vagina
What are the main antibodies seen in Sjogren’s?
Anti-Ro
Anti-La
How is Sjogren’s treated?
Artificial tear supplements
Ciclosporin eye drops
Hydroxychloroquine
What are the pathological features of systemic sclerosis?
Vascular endothelial changes
Fibrosis
What sites are affected in diffuse cutaneous systemic sclerosis?
Skin proximal to forearms and torso
Name the main antibodies seen in diffuse cutaneous systemic sclerosis
Anti-topoisomerase
Anti-SCL-70
Anti-RNA III polymerase
What sites are affected in systemic sclerosis?
Skin distal to forearms
What antibody is seen in systemic sclerosis?
Anti-centromere
Give some clinical features of systemic sclerosis
Sclerodactyly
Calcinosis
Heartburn
Interstitial lung disease
