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OSSF > Connective Tissue > Flashcards

Connective Tissue Flashcards

1
Q

What is the embryotic origin of CT?

A

Mesoderm

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2
Q

What intermediate filaments does CT have?

A

Vimentin

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3
Q

What is the most common cell in connective tissue proper?

A

Fibroblasts

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4
Q

What is the primary function of fibroblasts?

A

Production of all components of extracellular matrix fibers

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5
Q

What are the two types of histiocytes?

A

-Tissue Macrophage
-Dendritic cells

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6
Q

What is the function of a dendritic cell?

A

They present foreign molecules to t-lymphocytes

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7
Q

What is the fixed macrophage called in the brain?

A

microglial

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8
Q

What is the fixed macrophage called in the liver

A

kupffer cell

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9
Q

What is the fixed macrophage called in the lung

A

alveolar macrophages

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10
Q

What is the fixed macrophage called in the kidney

A

mesangial cell

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11
Q

What is the fixed macrophage called in the bone

A

osteoclasts

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12
Q

What are in mast cell cytoplasmic granules?

A

Histamine, heparin, proteases

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13
Q

How can you tell the difference between a macrophage and a plasma cell?

A

A plasma cell will have a dark, round, eccentric nucleus

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14
Q

What is the most abundant CT fiber?

A

Collagen

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15
Q

What is the strongest, most common type of collagen ?

A

Type I

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16
Q

What type of collagen is only found in cartilage?

A

Type II (hyaline)

17
Q

What type of collagen supports organs?

A

Type III (reticular)

18
Q

What type of collagen is in basement membranes?

A

Type IV

19
Q

What type of collagen in non-fibrillar?

A

Type IV

20
Q

How do you differenciate smooth muscle from dense regular type I CT?

A

smooth muscle will have more nuclei and more organized

21
Q

What type of collagen does silver stain for?

A

reticular fibers of type III collagen

22
Q

How are elastin organized into fibers?

A

Fibrillin is a protein that organizes elastin into fibers

23
Q

What happens to elastin if no fibrillin is present?

A

elastin forms elastin sheets (lamellae)

24
Q

What 3 stains can you use to identify elastic fibers?

A

-Verhoeffs-Van Gieson
-Orcein
-Resorcin-fuchsin

25
Q

How can you distinguish between reticular fibers and elastic fibers?

A

The type of stain you use

26
Q

What GAG does not have to bind to a protein core?

A

Hyaluronate

27
Q

What is a proteoglycan?

A

GAG linked to a protein core

28
Q

What is an important proteoglycan in cartilage? Why?

A

Aggrecan, resistant to compression

29
Q

Why does loose CT not stain well and appear with alot of white space?

A

Because it contains few fibers but abundant ground substance which doesn’t stain well

30
Q

What is CT ground substance?

A

an amorphis soup composed of GAGs, glycoproteins, and proteoglycans

OSSF (37 decks)

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