Common Drugs

Question 1

SE of Sulfasalazine?

Answer 1

haemolytic anaemia

(it is a DMARD + aminosalicylate)

Question 2

SE of Bisphosphonate?

Answer 2

oesophagitis, osteonecrosis of jaw, atypical fractures

Question 3

SE of Methotrexate?

Answer 3

gout, TERATOGENIC!!!

(also due to thiazide/loop diuretics)

Question 4

SE of Rifampicin?

Answer 4

red urine/sweats

(Tx for TB)

Question 5

SE of Isoniazid?

Answer 5

peripheral neuropathy

(so often co-prescribed with Pyridoxine)
(Tx for TB)

Question 6

SE of Ethambutol?

Answer 6

visual impairment

(Tx for TB)

Question 7

SE of Pyrazinamide?

Answer 7

joint pain, gout, rashes

(Tx for TB)

Question 8

SE of CCB?

Answer 8

ankle swelling

Question 9

SE of ACEi?

Answer 9

dry cough

Question 10

CI of Verapamil?

Answer 10

HF

(since it is a -ve inotrope)

Question 11

SE of Vancomycin?

Answer 11

nephrotoxicity

Question 12

SE of SGLTi (e.g. dapaglifozin)?

Answer 12

thrush, UTIs

(acts on PCT so more glucose is excreted in urine)

Question 13

Tx for Alzheimer’s?

Answer 13

Rivastigmine

(cholinesterase inhibitor)

Question 14

Meningitis:
Abx in GP?
Abx in hospital?

Answer 14

GP:
IM benzylpenicllin

Hospital:
IV ceftriaxone

Question 15

Abx for trichomonas vaginalis?

Answer 15

Metronidazole

Question 16

Tx for anaphylaxis?

Answer 16

500mg IM adrenaline

Question 17

Tx for high HbF (in sickle cell)?

Answer 17

hydroxyurea

Question 18

Tx for malignant HTN?

Answer 18

IV labetalol / GTN

Question 19

SE of Spironolactone?

Answer 19

gynaecomastia (in males)

Question 20

What should be monitored with ACEi + Spironolactone?

Answer 20

U&Es (for high potassium)

Question 21

SE of Adenosine?

Answer 21

impending sense of doom

Question 22

SE of Cabergoline?

Answer 22

mouth ulcers

Question 23

SE of Tamsulosin?

Answer 23

postural hypotension, retrograde ejaculation

Question 24

Why would Propylthiouracil be prescribed?

Answer 24

to treat hyperthryoidism in a pregnant woman

(Carbimazole = normally 1st line but is TERATOGENIC!!!)

Question 25

MOA of Ondansetron?

Answer 25

5-HT 3 receptor antagonist

(anti-emetic)

Question 26

MOA of Metoclopramide?

Answer 26

D2 receptor agonist

Question 27

CI of Trimethoprim?

Answer 27

pregnancy (teratogenic in 1st trimester)

Question 28

CI of Nitrofurantoin?

Answer 28

pregnancy (teratogenic in 3rd trimester)

Question 29

UTI: When would Amoxicillin or Cefalexin be used?

Answer 29

UTI in a pregnant woman

Question 30

Using Amiodarone + Erythromycin together?

Answer 30

increases risk of ventricular arrhythmias

(since both prolong the QT interval)

Question 31

SE of Amiodarone?

Answer 31

slate-grey appearance of skin

Question 32

2 DMARDs that may be used to prevent attacks of MS?

Answer 32

beta-interferon
monoclonocal Ab

Question 33

Abx which inhibit cell wall synthesis?

Answer 33

Penicillins, Vancomycin, Carbapanems, Cephalosporins

Question 34

Abx which inhibit folate synthesis?

Answer 34

Trimethoprim, Sulfonamides

Question 35

Abx which damage DNA?

Answer 35

Metronidazole

Question 36

Abx which inhibit DNA topoisomerase?

Answer 36

Quinolones

Question 37

Abx which inhibit RNA polymerase?

Answer 37

Rifampicin

Question 38

Abx which inhibit 30S subunit?

Answer 38

Aminoglycosides, Tetracyclines

Question 39

Abx which inhibit 50S subunit?

Answer 39

Macrolides, Clindamycin

Question 40

SE of Lamotrigine?

Answer 40

Steven-Johnson Syndrome

Question 41

SE of Vancomycin/Teicoplanin?

Answer 41

nephrotoxicity

Question 42

SE of Gentamycin?

Answer 42

nephrotoxicity + ototoxicity (i.e. hearing problems)