Colorectal Cancer. Flashcards
Diagnosis and management fo polyps?
Colonscopy and polypectomy.
Most colorectal cancers are what?
Are adenocarcinoma.
Risk factors for colorectal cancer?
Age, Male, Polyps, IBD.
Lo fibre, high red meat, smoker, alcohol, obesity.
Genetics of colorectal cancer?
FAP: Hereditary mutation in AOPC that predisposes to early onset colorectal cancer
HNPCC: Hereditary mustations in DNA mismatch repairs proteins that predispose to colorectal, ovarian and endometrial cance.r
WHere does it metastasise to?
Liver lung bone Peroitoneal.
Screening is offered to who?
50-74
New test?
qFIT, much more specific, gives a value based on haemaoglobin.
Positive result seen in 2% with 10% of positive results being cancer.
DUKES stage 1-4?
1) confined to mucosa
2) Tumout invaded through the bowel wall.
3) Involvement of local lymph nodes
4) Distant mets.
What monoclonal antibody can be used for dukes stage 4 and distant mets?
Cetuximab.
Cancer marker?
CEA
How do you stage a colonic tumour/?
How do you stage a rectal tumour?
Colonic = Ct CAP
Rectal = MRI.
Chemo-therapy also offered to most people
5FU and oxaliplatin.
