Class 6 Flashcards
Neoplasm
Uncontrolled cell growth
Cell differentiation
Become specialized
Autonomous neoplastic cell proliferation
independent of normal growth factors
Excessive neoplastic cell proliferation
No response to normal regulators
Disorganized neoplastic cell proliferation
disorganized compared to formation of normal tissues
Benign tumor
limited, slower growth
Malignant
more growth, poor outcome
Benign tumor macroscopic feature
Sharply demarcated
Encapsulated CT tissue
Benign tumor microscopic feature
Cells are similar
Benign tumor cellular feature
Uniform cell populations,
regular shape and size
Benign tumor chromosomal features
Normal chromosome numbers
Benign tumor biological features
Normal complex functions
Malignant tumor macroscopic features
No clear border or encapsulation
Malignant tumor macroscopic features (2)
Look different, unspecialized
anaplasia
backwards growth - specialized to unspecialized
Malignant tumor microscopic features
Cells have different sizes and shapes
Malignant tumor chromosomal features
Aneuploid - abnormal # chromosomes
Metastasis
Cells move to another body site
Malignant tumor biological features
No specialization
Which tumors metastasize
Malignant tumors
Metastasis 3 pathways
lymph, blood, body cavities
Metastatic cascade
Malignant cells able to clone and move to new sites
What is angiogenesis
Malignant tumor forms new blood vessels to spread
Benign tumors end with…
“-oma”
Fibroblast benign tumor
Fibroma
Cartilage benign tumor
Chondroma
Adipose benign tumor
Lipoma
Smooth muscle benign tumor
Leiomyoma
Bone benign tumor
Osteoma
Striated muscle benign tumor
Rhabdomyoma
Benign tumor from epithelial cells
Adenoma
Root for malignant tumor
“sarcoma”
Malignant tumor from fibroblast
Fibrosarcoma
