Class 4 Flashcards
Immunity
Protection from diseases
Natural immunity
Born with it
Acquired immunity
Develop with exposure
Primitive natural immunity
nonspecific form of immunity
Inherited natural immunity
Not dependent on previous exposure
Natural immunity includes which cell type?
NK cells
Properdin
Plasma protein activate alternate complement pathway
Lysozyme
protein in tears, nasal secretion
Acquired immunity based on
Responses stimulated by antigens
Antigen
chemical substance elicit immune response
immunocompetance
ability to mount an appropriate immune response
Lymphocytes
bone marrow stem cells giving rise to two cell types
Lymphocytes derive into
T-lymphocytes, B-lymphocytes
T lymphocytes mature in?
thymus
B lymphocytes mature in?
Bone marrow
Primary lymphoid organs
bone marrow and thymus
Secondary lymphoid organs
spleen and lymph nodes
NK Cells functions
kill tumor and foreign cells
T Helper (CD4+) Cells funtions
help B cells produce antibodies
secrete cytokines
T suppressor (CD8+) Cell function
Supress unwanted antibody prod.
Ratio of CD4+/CD8+ ?
2:1
Antibodies are
Proteins secreted by plasma cells, help fight antigens
B lymphocyte functions
Differentiate into antibody
Plasma Cells synthesize?
Contain ribosomes and RER - antibody synthesis
IgM
Largest immunoglobin, first to appear
IgG
Smallest, most abundant
IgA
In mucosal secretions
IgE
Mediates allergic reactions
Secreted in tissues/ attached to mast cells
IgD
Exclusive to B cells
Antibody production begins with
contact between antigen and immune system cells
antigen-presenting cells (APC) are
B-cells internalizing antigen presenting to T-Cells
Antibody production requires support of
T Helper Cells
T-Helper cell produces
Cytokines
Cytokynes transform B-cell into
Plasma cell
Plasma cell produces
Antibodies
AgAb complexes bind on RBC’s cause
Agglutination
Hay Fever is Type ?
Type 1 hypersensitivity
Atopic dermatitis (eczema) type?
Type 1 hypersensitivity
Bronchial asthma type?
Type 1 hypersensitivity
Anaphylactic shock type?
Type 1 hypersensitivity
Type 2 mediated by
IgG or IgM
Goodpastures syndrome type?
Type 2 hypersensitivity
Hemolytic anemia type?
Type 2 hypersensitivity
Graves disease type?
Type 2 hypersensitivity
Myasthenia Gravis type?
Type 2
SLE and Post-streptococcal type
Type 3
Polyarteritis Nodosa type?
Type 3
Type 4 hypersensitivity causes
Aggregate and form granulomas at injury site
Transplantation is?
Solid tissue transplant
Autograft
Self donor
Isograft
Identical twins
Homograft
Same species/not identicalX
Xenograft
Transplant b/w species