Class 3 - Cardiovascular Flashcards
Arteriosclerosis
Thickening/loss of elasticity of arterial walls. “Hardening”
Monckebergs Arteriosclerosis
Middle layer of artery destruction and formation of calcium deposits. Age related (old).
Arteriolosclerosis
Thickening of walls of arterioles. Hypertension related.
Atherosclerosis
Thickening of arterial wall. Formation of plaque and narrowing of arterial lumen. Body sends macrophages to the area, which get stuck. M/c type
Atherosclerosis Complicated lesion
Atherosclerosis buildup eventually can cause surface defect which leads to thrombosis/embolism.
Coronary artery disease
Atherosclerosis of coronary arteries
Peripheral vascular disease
atherosclerosis of arteries supplying extremities/organs
Cerebrovascular disease
atherosclerosis of arteries that supply brain
Atherosclerosis Clinical manifestation
Asymptomatic, ischemia, infarct
Atherosclerosis etiology/risk factors
high cholesterol, high BP, obesity, genetics, smoking, age, diabetes
Atherosclerosis Diagnosis
Cholesterol check, angiogram, ECHO, stress test, US, MRI
Atherosclerosis Treatment
Modify/reduce risk factors, exercise, medications
Exercise good longterm
Peripheral Vascular Disease
narrowing of circulatory system outside brain/heart
Peripheral Vascular Disease Incidence
Increases with age (>50), Men > women
PVD location
More common in LE
PVD etiology
M/c result of atherosclerosis
PVD Symptoms
Intermittent claudication (lack of blood), pain, cyanosis, fatigue, gangrene, cold extremities
Vasculitis
Inflammation of blood vessel
Arteritis
Inflammation of artery
Infective arteritis
Inflammation of artery due to infection
Rheumatoid arteritis
Inflammation of artery associated w/ RF/RHD
Giant Cell Arteritis (temporal arteritis)
Vasculitis involving multiple sites of temporal/cranial arteries
Giant Cell Arteritis Incidence and Risk factors
M/c in US, Women > men, SLE and RA related
Giant Cell Arteritis Etiology
Idiopathic, multifactorial, genetic, infectious, hormonal
Giant Cell Arteritis Clinical Manifestation
Sudden onset, throbbing headache, visual disturbances (ophthalmic artery), polymyalgia, heart murmur, enlarged temporal artery, jaw/tongue claudication
Giant Cell Arteritis Diagnosis
Based on symptoms, palpation, blood tests, biopsy
Giant Cell Arteritis Treatment/Prognosis
Anti-inflammatories and corticosteroids. May lead to blindness if untreated
Thromboangiitis Obliterans (Buerger’s Disease)
Vasculitis affecting peripheral blood vessels in distal extremities
Thromboangiitis Obliterans Etiology/Risk Factors
Idiopathic. Men who smoke > women
Thromboangiitis Obliterans Pathogenesis
Inflammatory lesions leads to thrombus formation and occlusion. Eventually obliterates small/medium vessels in feet/hands
(lack of blood flow to fingers and toes)
Thromboangiitis Obliterans Clinical Manifestation
Intermittent claudication, pain, edema, cold sensitivity, cyanosis
Thromboangiitis Obliterans Complications
Ulcerations, Gangrene
Thromboangiitis Obliterans Treatment/Prognosis
Cessation of smoking, increase circulation, medication, amputation
Polyarteritis Nodosa
Systemic inflammation and necrotic lesions in the arterial system. Damaging organs, mm, joints, skin - not lungs
Polyarteritis Nodosa Etiology
Idiopathic
Polyarteritis Nodosa Clinical Manifestation
aneurysms in affected arteries, subcutaneous nodules, rash, muscle/joint pain
Polyarteritis Nodosa Diagnosis
Blood test, imaging, biopsy
Polyarteritis Nodosa Treatment
Medication
Polyarteritis Nodosa Prognosis
Poor without treatment, good with treatment
Aneurysm
Abnormal stretching in wall of blood vessel over 50% greater than normal
Aneurysm Classification
Based on location, pathology, type of vessel
Aortic Aneurysm
M/c site is abdominal > thoracic
Thoracic Aneurysm
Involves ascending, transverse, or first part of descending aorta
Abdominal Aneurysm
Aorta b/w renal arteries and iliac branches
Mycotic Aneurysm
Caused by bacteria or fungal, salmonella or syphilis
Atherosclerotic Aneurysm
Build up of fatty deposits inner walls of arteries
Aneurysm Etiology/Risk factors
Age, congenital connective tissue weakness, genetics
Aneurysm Pathogenesis
Plaque formation erodes vessel wall predisposing vessel to stretching and formation of a sac
Aneurysm Diagnosis
CT (done with dye), palpation
Aneurysm Clinical Manifestation
Variable, asymptomatic, pain, dyspnea, cough, hoarseness, edema, distended neck veins
Aneurysm Treatment
Watch/wait, surgery, medication
Aneurysm Prognosis
Poor