Citroni Tutorial #3 Flashcards
What is SIRS stand for?
systemic inflammatory response syndrome
what happens in SIRS?
fenetrations in the intravascular compartment get larger, too much Na+ in ECF
where does H20 go in the compartments?
EVERYWHERE (all 3)
What is the 3rd space?
ECF
what holds water in the ECF?
glycoprotein matrix
what holds water in the intracellular compartment?
Na/K+ pump
what does Na/K+ pump do to intracellular and ECF?
makes a concentration gradient
is ECF usually measured?
only in pathology, etc. ascites
what holds fluid in the intravascular compartment?
Albumin
conc. of K+ intracellular?
~140mmol/L
conc. of K+ intravascularly?
3.5-5mmol/L
conditions where you get hypervolaemia?
Heart and liver failure
what happens in isovolaemia?
increased H20, normal Na+
what conditions cause isovolaemia?
H20 intoxication
what can severe hyponatraemia cause?
cerebral oedema
seizures
2 causes of hypovolaemia?
thiazides
addisonian state
why do you not give 5% dextrose after surgery?
due to SAADH, would cause H20 toxicity
How to correct acute Hyponatraemia?
quickly up to symptom relief (no seizures around 115-120), then go slow up to 140
side effect of overcorrection of hypoNa+?
CPM
central pontine myelosis
how slow to correct chronic hypo-natraemia?
is normal saline normal? why?
Nope: 150mmol/L of Cl when physiological is (95-105)
Diabetes insipidus urine output can be?
> 200-1000ml/hr
how does ADH work?
aquaporins translocate to collecting ducts, absorbs water
specific gravity of someone with D.I.?
