Cirrhosis

Question 1

Cirrhosis

Answer 1

Diffuse fibrosis and nodular regeneration, destroys normal architecture of liver

Increased risk of HCC

Question 2

Etiologies

Answer 2

Alcohol (60-70%)
Viral hepatitis
Biliary disease
Hemochromatosis

Question 3

Effects of liver failure

Answer 3

Coma
Scleral icterus
Fetor hapticus (breath smells musty)

Spider nevi
Gynecomastia
Jaundice
Testicular atrophy

Liver flap =asterixis
Bleeding tendency
Anemia
Ankle edema

Question 4

Reye’s syndrome

Answer 4

Rare often fatal childhood hepatoencephalopathy
Finding: mitochondrial abn, fatty liver, hypoglycemia, vomiting, hepatomegaly, coma.

Associated with viral infection (VZV, influenza B) treated with aspirin.

MOA: aspin metabolite decreases beta oxidation by reversible inhibition of mitochondrial enzymes