Alcoholic liver disease

Question 1

Hepatic steatosis

Answer 1

Short term change in moderate alcohol intake

Macrovesicular fatty change that may be reversible with alcohol cessation

Question 2

Alcoholic hepatitis

Answer 2

Sustained, long-term consumption
Swollen and necrotic hepatocytes with neutrophilic infiltration

Mallory bodies (intracytoplasmic eosinophilic inclusions)

Question 3

Alcoholic cirrhosis

Answer 3

Final and iireversible
Micronodular, irregularly shrunken liver with Hobnail appearance
Sclerosis around central vein (zone3)
Manifestations of chronic liver disease (jaundice, hypoalbumin)