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PHM 702- Asthma, Allergic Rhinitis, COPD > Chronic COPD- PDE4 DI > Flashcards

Chronic COPD- PDE4 DI Flashcards

1
Q

PDE4i used in COPD

A

Roflumilast

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2
Q

Roflumilast MoA

A

Reduce inflammation by inhibiting breakdown of intracellular cAMP

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3
Q

Roflumilast ADEs

A

Nausea, diarrhea, weight loss (caution in those with low BMI), sleep disturbance, headache, may worsen depression/associated with suicidal ideation

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4
Q

Rofllumilast DDIs

A

3A4 inhibitors, 3A4 and 1A2 inducers, theophylline

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PHM 702- Asthma, Allergic Rhinitis, COPD (50 decks)

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