AR- Intranasal Corticosteroids

Question 1

Intranasal corticosteroids

Answer 1

Beclomethasone

Budesonide

Flunisolide

Fluticasone propionate and furoate

Mometasone

Triamcinolone

Ciclesonide

Question 2

Intranasal corticosteroids MoA

Answer 2

Reduce inflammation by suppressing mediator and cytokine release and recruitment of neutrophils, basophils, eosinophils, and mononuclear cells

Reduce antigen-induced hyperresponsiveness of the nasal mucosa to subsequent challenge by antigen and histamine release

Question 3

Intranasal corticosteroids symptom targets

Answer 3

Congestion
Rhinorrhea
Sneezing
Nasal itching
Ocular symptoms

Question 4

Intranasal corticosteroids ADEs

Answer 4

HA, dryness, burning, stinging, blood-tinged secretions, epistaxis (nosebleeds)

HPA suppression unlikely

Growth suppression in children

Question 5

Avoid intranasal corticosteroids in what patients?

Answer 5

Nasal septum ulcers, recent nasal surgery, trauma

Question 6

Patients with what disease will have more systemic absorption of intranasal corticosteroids?

Answer 6

HIV

Question 7

Intranasal corticosteroids with the least effects on growth suppression

Answer 7

Fluticasone, mometasone, triamcinolone