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PHM 702- Asthma, Allergic Rhinitis, COPD > Chronic Asthma- LTRAs DI > Flashcards

Chronic Asthma- LTRAs DI Flashcards

1
Q

LTRAs

A

Montelukast
Zafirlukast
Zileuton

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2
Q

LTRAs MoA

A

Block proinflammatory leukotrienes at receptor sites to reduce airway constriction and mucous secretion

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3
Q

Montelukast ADEs

A

HA, URTI, N/V/D, psychiatric changes

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4
Q

Montelukast BBW

A

Mental health effects (agitation, aggression, suicidal thoughts)

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5
Q

Zafirlukast ADEs

A

HA, liver failure, neuropsychiatric Sx

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6
Q

Zafirlukast DDIs

A

Warfarin, aripiprazole, theophylline

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7
Q

Zileuton ADEs

A

N/V/D, HA, hepatotoxicity, neuropsychiatric symptoms

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8
Q

Zileuton DDIs

A

Theophylline, ramelteon, ergot alktaloids

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9
Q

What are LTRAs used for in asthma treatment?

A

MAINTENANCE (but NOT first line!)

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PHM 702- Asthma, Allergic Rhinitis, COPD (50 decks)

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