Chole Flashcards
- What is the prevalence of gallstones in developed countries?
10-15%.
- What are the risk factors for gallstone formation?
Age
- What is the role of cholesterol in gallstone formation?
Cholesterol hypersecretion leads to bile supersaturation and stone formation.
- What are the types of gallstones?
Cholesterol stones (80%) and pigment stones (black and brown).
- What are black pigment stones associated with?
Hemolytic disorders like sickle cell disease and cirrhosis.
- What are brown pigment stones associated with?
Biliary stasis and bacterial infection.
- What is the natural history of asymptomatic gallstones?
80% remain asymptomatic
- What are the complications of gallstone disease?
Acute cholecystitis
- What is the typical presentation of biliary colic?
Severe
- What is Murphy’s sign?
Inspiratory arrest during deep palpation of the RUQ
- What is the diagnostic test of choice for gallstones?
Abdominal ultrasound.
- What is the treatment for symptomatic gallstones?
Laparoscopic cholecystectomy.
- What is the role of ERCP in gallstone disease?
To diagnose and treat choledocholithiasis.
- What is the TG18 severity grading for acute cholecystitis?
Grade I (mild)
- What is the treatment for acute cholecystitis?
Early laparoscopic cholecystectomy within 72 hours of symptom onset.
- What is acalculous cholecystitis?
Acute inflammation of the gallbladder without gallstones
- What is the treatment for acalculous cholecystitis?
Percutaneous cholecystostomy or cholecystectomy.
- What is choledocholithiasis?
The presence of stones in the common bile duct.
- What are the clinical features of choledocholithiasis?
Biliary colic
- What is the gold standard for diagnosing choledocholithiasis?
ERCP.
- What is the treatment for choledocholithiasis?
Endoscopic sphincterotomy and stone extraction
- What is acute cholangitis?
An ascending bacterial infection of the bile ducts
- What is Charcot’s triad?
Fever
- What is Reynolds’ pentad?
Charcot’s triad plus septic shock and mental status changes
- What is the treatment for acute cholangitis?
IV antibiotics and urgent biliary drainage (endoscopic or percutaneous).