Chapter 7: 2.2 - Interstitial Disorder & Renal Failure Flashcards
infection of the renal pelvis
pyelitis
infection of the renal pelvis and the interstitium
pyelonephritis
-majority of interstitial disorder involve: (2)
- infections
2. inflammatory conditions
- caused by ascending bacterial infection of the bladder
- more often seen in women
cystitis
- most often occurs as a result of lower UTI (untreated cystitis)
- presence of persistent backflow of urine from the bladder into the ureters or kidney pelvis.
Acute Pyelonephritis
- serious disorder that can result in permanent damage to the renal tubules and possible progression to chronic renal failure
Chronic Pyelonephritis
- recurrent infection of the renal tubules and interstitum
- caused by (congenital) structural abnormalities affecting the flow of urine.
Chronic Pyelonephritis
- an allergic inflammation of the renal interstitium followed by inflammation of the renal tubules in response to certain medications.
Acute Interstitial Nephritis
-symptoms of acute interstitial nephritis tend to develop aprroximately _____ following administration of medication.
2 weeks
Penicilin, methicillin, ampicillin, cephalosporins, sulfonamides, NSAIDs, furosemide, and thiazide diuretics
Medications commonly associated with Acute Interstitial Nephritis
- exists both acute and chronic forms
- chronic forms may be a gradual progression form the original disorder to chronic renal failure or end-stage renal disease
Renal Failure
GFR 50% normal
Diminished renal function
GFR = 20-50% of normal
Renal insufficiency
GFR = <20% of normal
Renal failure
GFR <5% of normal
End stage renal disease