Chapter 5 - Integumentary System Flashcards
What are the characteristics specific to the epidermis
Primary cellular
Keratinized stratified epithelium
Vascular
Separated from dermis by basement membrane
What are the three layers of skin
Epidermis
Dermis
Hypodermis
What are skins specific characteristics
Largest organ
Covers external surface of body
Composed of all 4 tissue types
What are the characteristics specific to the dermis
Has projections: dermal papillae
Vascularized
Contains muscle and nervous tissue
What are the characteristics specific to the hypodermis
Composed mostly of adipose tissue
Vascularized
What is skin composed of
Stratified squamous epithelium
What is specific about stratified squamous epithelium
Contains keratinocytes Dominant cell type in epidermis Produces keratin Along basement membrane Basal layer divides by mitosis
How do cells become Keratinized
Lose nucleus, organelles, flatten and die
What are melanocytes
Produce keratin = dark pigment
Have octopus like projections
Melanin is released and absorbed by keratinocytes
What is a langerhans cells
Macrophage specific to epidermis Wander through epidermis Phagocytizes pathogens Stimulates immune system Formed in bone marrow and migrate to skin via blood
What is a merkel cell
Epithelial cells found at base of epidermis
Associated with sensory nerve endings
What type of cells cause skin cancer
Squamous cell carcinoma
Malignant melanoma
Basal cell sarcoma
What is specific about squamous cell carcinoma
Found in areas most exposed to u.v.
Aggressive locally - forms lesions
Spreads rapidly to lymph nodes:deadly
What is specific about malignant melanoma in horses
Very common in Greta
Start as nodules on ears,perianal area
Later ulcerate and spread to rest of body
What is specific about malignant melanoma in dogs
Oral cavity is the most common location and it is the most malignant
What is specific about basal cell tumours
Affect basal layer Nodular masses beneath skin Usually benign and don't spread More common in cats than dogs Found in head + neck region
What is the first layer of epidermis and what is specific about it
Stratum basale:
Single row of keratinocytes on top of basement membrane
Actively dividing
Newly forming cells are pushed upwards
What is the second layer of epidermis and what is specific about it
Stratum spinosum:
Several rows of keratinocytes
Cell layers held together by desmosomes
Projections of melanocytes reach into this layer
What is the third layer of epidermis and what is specific about it
Stratum granulosum:
2-4 rows of cells; flattened-diamond shaped keratinocytes
What is the fourth layer of epidermis and specific characteristics of it
Stratum lucidum:
Found only in thick skin
Few layers of Keratinized dead cells
What is the fifth layer of epidermis and what is specific about it
Stratum corneum:
Outermost layer
Majority of epidermis thickness
20-30 rows of dead, flattened keratinocytes
What is specific about the dermis?
Provides structural strength to skin
Hide of animal used to make leather
Contain large amount of fibers: collagen, elastic, reticular
Cells: fibroblasts
What are the two layers of the dermis:
Papillary layer
Reticular layer
Describe the papillary layer
Thin, superficial layer
Below basement membrane
Composed to Areolar connective tissue ** ground substance? Hyaluronic acid
WhAt is special about the papillary layer
Often has papillae rising up into epidermis and has sensory neurons
Describe the reticular layer
Thick, deep layer
Composed 80% of dermis
Composed of dense irregular connective tissue