Chapter 45 - Neurologic complications Flashcards
Blood supply to the nerve
1) vasa nervorum
2) diffusion
Time threshold for irreversible nerve injury
6-10 hours (in animals)
Ischemic monomelic neuropathy
No axonal degeneration and demyelination
Altered flow through vasa nervorum cause acute conduction block
persistence –> distal axonal infarction
Chronic ischemic neuropathy vs acute pathology
pathogenesis appears to be the same
Neurapraxia definition
transient nerve dysfunction
Common causes of unilateral neuropathy
1) entrapment
2) trauma
3) ischemia
4) vasculitis
Common causes of bilateral neuropathy
1) metabolic (diabetes, uremia)
2) toxic (alcohol, drugs, metal)
3) connective tissue disease, vasculitis
4) deficiency (vitamin)
5) inflammatory
6) monoclonal gammopathies
7) HIV infection
Ischemic neuropathy in lower extremity presentation
1) unilateral sensory loss - stocking distribution; especially vibration
2) ankle weakness
3) depressed ankle reflex
Distal latency and velocity of conduction in ischemic neuropathy vs diabetic and uremic neuropathy
well preserved in ischemic neuropathy
reduced in a symmetrical bilateral way in diabetic/uremic neuropathy
Sensory nerve in ischemic neuropathy
Absent sensory potential amplitude but velocity is normal
First line treatment for pain control - ischemic neuropathy
1) TCA
2) SSRI
3) Calcium channel alpha-2 delta (Gabapentin, pregabalin)
Peripheral nerves matched to nerve roots
Axillary - C5, C6 Musculocutaneous nerve - C5, C6 Median nerve C5-T1 Radial C5-C8 Ulnar C8, T1
Nerve injury during axillary artery exposure
Cords of the brachial plexus
Nerve injury during brachial artery exposure
Median nerve
Ulnar nerve
Nerve injury from positioning
Ulnar nerve