Chapter 31 ACEI and ARBS Flashcards

1
Q

What is the last name for ARBS

A

“-sartan”

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2
Q

What is the last name for ACEI’s

A

“-pril”

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3
Q

what is the prototype ARBS

A

Losartan

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4
Q

What is the prototype ACEI

A

Lisinopril

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5
Q

what are the 4 steps of the Renin Angiotensin aldosterone system

A
  1. Angiotensinogen is produced by the liver
  2. Angiotensinogen is converted to angiotensin 1 by renin which is secreted by the kidneys
  3. ACE secreted from the lungs converts Angiotensin 1 to angiotensin 2
  4. Angiotensin 2 causes vasoconstriction and releases aldosterone and ADH
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6
Q

why can ACEI’s create angioedema

A

because ACE is also responsible for the breakdown of bradykinin which is a mediator of inflammation

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7
Q

What are three indications for ACEI’s

A

-Heart failure
-Recent MI
-If patient is in danger of kidney damage from HTN

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8
Q

What are contraindications for ACEI’s and ARBS

A

-Hyperkalemia (because ACEI messes with excretion of K+)
-Symptomatically hypotensive (will tank the PT)
-Renal failure (since ACEI are excreted by the kidneys)

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9
Q

What are adverse effects of ACEI

A

-Cough (build up of bradykinin)
-Orthostatic hypotension
-Angioedema

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10
Q

What are considerations for ACEI

A

-Check lab levels of K+
-Check BP before administration and 30 min to 1 hour after

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11
Q

What are drug interactions for ACEI and ARBS

A

-K+ supplements (ACEI and ARBS both reduce the excretion of K+ from the kidneys)
-other drugs that lower BP
-NSAIDS because they decrease effectiveness

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12
Q

what are ARBS effect on bradykinin

A

they do not affect the breakdown of bradykinin so they do not produce a cough like ACEI do

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13
Q

What pregnancy category are ACEI and ARBS

A

Both are pregnancy category D

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14
Q

what is one downside of ARBS compared to ACEI

A

ARBS are more expensive than ACEI

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