Chapter 3 (Methods) Flashcards

1
Q

What is cognitive psychology?

A

Study of mental activity as an information processing problem

Perceptions, thoughts and actions depend on internal transformations

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2
Q

Correlation vs Causation

A

Correlation - relationship between 2 variables
Causation - change in one variable causes a change in the other

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3
Q

What is chronometrics?

A

Reaction time is proportional to mental processing

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4
Q

Alzheimer’s disease

A

Amyloid plaques, analyzed post mortem

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5
Q

What is the Stroop effect?

A

Stroop effect - delay in reaction time due to multiple stimuli
Stroop test - say the color of the font each word is printed in
Worse at task when word and color are mismatched (interference)
- Physical color of text (task-relevant)
- Color concept/meaning (irrelevant to task)

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6
Q

Posner vowels/consonants experiment

A

Task - raise left hand for same (2 vowel, 2 consonant) raise right hand for different
Steps (encode, compare, decide, respond)

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7
Q

Basic uses of eye-tracking

A

Use eye movements/ gaze patterns to tap into mental processes.

Where are they looking, do they return to previous locations, how frequently do they make saccades (where we move our eyes)

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8
Q

Purpose of computer modeling

A

Use computers as a metaphor for the brain in order to study human cognition

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9
Q

Limitations of computer modeling

A

Simplification of nervous system
Not biological
Small in scale, narrow problems

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10
Q

Intracellular Recording

A

Tip of microelectrode is inserted inside cell, so membrane potential can be measured. Invasive. Thin electrode inserted into cortex.
- Graded membrane potentials
- Very difficult

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11
Q

Extracellular Recording

A

Allows investigator to record discharges of single neuron without impalement.
- action potentials (“spikes”)
- more common

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12
Q

Relevance of a neuron’s baseline activity

A

Neurons are constantly active
Need to use baseline activity as a control for stimulation

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13
Q

What is a receptive field

A

Location in space for which neuron is responsive

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14
Q

Limitations of single cell recording

A

Invasive, poor spatial coverage, a single neuron is not representative of the whole brain/region, not humans, not causal (unless lesion)

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15
Q

What are animal lesions used for?

A

Used to see how neural structure contributes to task - if a part of brain removed, is the performance on task impaired?

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16
Q

What techniques can be used for animal lesions?

A

Aspirate tissue: destroy brain structure via suction

Electrolytic lesion: similar, using electrical charge

Neurochemical Lesion: designed to damage specific cells types only.

Reversible lesion: Cooling, pharmacological

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17
Q

What is a single dissociation?

A

Damage to one particular area of the brain (area X) impairs the ability to do task A, but not task B (you are dissociating task B from area X)

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18
Q

What is a double dissociation?

A

Damage to area X impairs the ability to do task A but not task B. Damage to area Y impairs ability to do task B but not task A.

19
Q

Can damage to a brain region tell you if it’s necessary and/or sufficient for a cognitive function?

A

No b/c of the HM model 1 was damaged but no impact on memory unless both were affected.

20
Q

What are genetic manipulations in animals?

A

Goal: find genetic basis for brain disorders.
Approach: produce genetic alterations in animals

21
Q

What does it mean to “knockout” rodents?

A

“knockout” mice where you replace gene and see how it affects their behavior - measure freezing behavior.

22
Q

What is TMS?

A

“Virtual Lesions”
- same logic as neuropsychology

23
Q

What is PET?

A

Measures local variations in cerebral blood flow (mostly replaced by fMRI)

24
Q

Difference between fMRI and MRI

A

MRI studies brain anatomy while fMRI studies brain function

25
Q

How does MRI work?

A

Applies a powerful magnetic field which makes protons parallel to field.
Then a radio frequency (RF) perturbs them and then they rebound to the MRI magnetic field.

26
Q

What does MRI measure?

A

How long it takes protons to rebound (by detecting energy released)

27
Q

How does fMRI work?

A

Focuses on oxygenated vs deoxygenated blood. More active brain area leads to more oxygen flowing through blood.

28
Q

What does BOLD mean.

A

Blood Oxygenation Level Dependent signal indirect measure of neural activity. The greater the neural activity, the higher the blood flow, the greater the fMRI signal

29
Q

What does fMRI measure?

A

Measures the time course of this process of oxygen absorption by looking at changes in BOLD overtime

30
Q

fMRI advantages

A

High spatial resolution
Simultaneous coverage of whole brain
Non-invasive

31
Q

fMRI limitations

A

Poor temporal resolution
Need lots of data
Purely correlational

32
Q

What is a voxel?

A

a three-dimensional square or rectangular chunk of brain tissue called a volume element

33
Q

What is an EEG?

A

electrodes on scalp record electrical signals

34
Q

What is ERP?

A

A type of EEG analysis
Activity related to sensory, motor, cognitive events

35
Q

EEG/ERP advantages

A

Great temporal resolution, inexpensive, accessible, non-invasive

36
Q

EEG/ERP limitations

A

Poor spatial resolution, challenges in localizing source (inverse problem)

37
Q

EEG vs MEG

A

MEG (magnetic) is a slightly different version of EEG (electrical) that solves the inverse problem and has better spatial localization

38
Q

Limitations of MEG

A

more expensive, less accessible

39
Q

What is ECoG?

A

Intracranial EEG (electrodes placed directly in/on brain)

40
Q

ECoG advantages

A

Excelled temporal and spatial resolution, recording directly from brain in humans

41
Q

ECoG limitations

A

Extremely invasive, no experimental control

42
Q

What are the uses for TMS?

A

Functional localization/specialization, Timing and Combining with neuroimaging

43
Q

What do DTI/DWI measure?

A

Use MRI to measure diffusion of water through axons