chapter 28-3

Question 1

T lymphocytes

Answer 1

T-cytotoxic (Tc) cells
-recognize antigen presented by MHC I.
-Kill antigen bearing target cells directly.
T-helper (Th) cells
-interact with per tide-MHC II complexes.
-act through cytokines to promote immune reactions.

Question 2

Response to Influenza

Answer 2

1. Virus infects cell.
2. Virus replicates and releases viral particles.
3. Interferon produced.
4. MHC 1 presents viral antigen activating cytotoxic T cells killing the cell that present the antigen.
5. Antibodies also produced.

Question 3

B cells

Answer 3

In an antibody-mediated immune response, helper T cells activate B cells which differentiate into plasma and memory cells.
Plasma cells excrete antibodies.
Memory cells are long lived.

Question 4

Antibodies

Answer 4

Antibodies (immunoglobulins) soluble proteins made by B cells.
B cells display antibodies and directly interact with antigens.
B cells ingest pathogen via phagocytosis.
B cells produce many antigens that are presented to antigen specific Th2 cells.

Question 5

Antibodies: Th2

Answer 5

Th2 cells do not interact directly with pathogen, stimulate other cells.
Activated B cells differentiate into plasma cells that produce soluble antibodies (primary antibody response).
Subsequent exposure to same antigen induces memory (secondary antibody response).

Question 6

Antibody functions

Answer 6

Stimulation of inflammation response.
Neutralization.
Opsonization.
Agglutination.

Question 7

Requirements for the adaptive response

Answer 7

Specificity.
Memory.
Tolerance.
-Discrimination between foreign and host antigens.