chapter 2: pet rpxs Flashcards
c11 acetate moa
fatty acid that tracks the krebs cycle
c11 acetate use
myocardial oxygen consumption, fatty acid metabolism in oncology
c11 acetate production
reaction of grignard reagant, methyl magnesium bromide, co11 2 gas, purification
c11 acetate patient prep for oncology
fast for 6 hours
most common oncology applications for c11 acetate
mainly prostate, also brain tumors and hepatic cancer
c11 acetate dose for oncology
20 mCi
c11 acetate imaging procedure for oncology
dynamic image over area of interest, or wait 5 min and perform “body scan”
c11 acetate normal areas of uptake
NO uptake in the brain, NO excretion in urinary system
c11 choline moa
water-soluble nutrient transported into cells as a precursor for biosynthesis of phospholipids. represents fatty acid metabolism
c11 choline use
primarily prostate cancer, also brain and colon
c11 choline production
cyclotron produced, converted to c11 methyl iodide, reacted with dimethylethanolamine and purified
c11 choline procedure
6 hour fast, 20 mCi (same as c11 acetate), delay 5-10 mins and perform “body images”
f18 sodium fluoride use, production, dose, moa
exchanged with po4 ions with hydroxyapatite crystals in bone
10 mCi, delay 1-2 hours, total body imaging. may perform dynamic or blood pool
from cyclotron target, is captured on carbonate anion column, washed with water, eluted and formulated with sodium chloride
f18 fluciclovine brand name
axumin
f18 fluciclovine moa
amino acid transport
where does f18 fluciclovine localize?
liver, pancreas, lung, bone marrow, myocardium, small amount excreted in urine
f18 fluciclovine production
nucleophilic substitution, similar to fdg
f18 fluciclovine procedure
void 30-60 mins before imaging. 10 mCi, begin imaging NO LATER than 4 mins post inj, start at mid thigh to base of skull. takes 20-30 mins
f18 fluoroestradiol brand name
cerianna
f18 fluoroestradiol moa
analog of estradiol. estrogen receptor mediated for breast cancer (ONLY ER +)
f18 fluoroestradiol production
nucleophilic substitution, provided as multidose vial from manufacturer
f18 fluoroestradiol dose/procedure
3-6 mCi, inject SLOW over 1-2 mins, hydrate during uptake, delay 20-80 mins (most sites do 80 min), scan eye to thigh
f18 PSMA piflufolastat brand name
pylarify
f18 piflufolastat production
nucleophilic substitution, requires high-performance liquid chromatography (HPLC) purification
f18 piflufolastat dose/procedure
8-10 mCi, delay 60-90 mins, void, scan mid-thigh to skull base. total scan time 12-40 mins
ga68 PSMA-11 (gozeotide) production
generator eluate must be chelated
ga68 PSMA-11 dose/procedure
3-7 mCi, delay 50-100 mins, void, scan from mid thigh to skull base
rb82 chloride moa
potassium analog, active transport via the Na/K ATP pump in myocardium
rb82 chloride production
Sr82 generator
Sr82 half life
25.6 days
n13 ammonia moa
trapped in myocardium by glutamic acid/glutamine reaction fixation of ammonia
n13 ammonia production
irradiation of high-purity water containing 5% ethanol
n13 ammonia dose/procedure
15 mCi, wait 2-3 mins and scan. perform stress 25-30 mins later
f18 fluorodopa production
electrophilic substitution using a stannyl(tin) based precursor or a multistep nucleophilic method. cyclotron must produce F2 (fluorine gas) for electrophilic method or F- form for nucleophilic method
f18 fluorodopa procedure
withhold medications for PD 12 hours prior, premedicate with 150 mg carbidopa 1 hour before injection. perform dynamic imaging to produce a Ki map
f18 florbetapir (amyvid) dose and uptake time
10 mCi, 30-50 min
f18 flutemetamol (vizamyl) dose and uptake time
5 mCi, 60-120 min
f18 florbetaben (neuraceq) dose and uptake time
8 mCi, 45-180 min
f18 flortaucipir (tauvid) production
nucleophilic radiofluorination of precursor AVV1622 followed by acid hydrolysis
f18 flortaucipir procedure and dose
10 mCi, wait 80 mins and image. no special prep required
normal areas of uptake for Ga68 DOTATATE/TOC/NOC
salivary glands, liver, spleen, pancreas, kidney, bladder
ga68 dota dose/procedure
3-5 mCi, wait 60-90 mins, perform WB imaging. may do dynamic imaging
cu64 DOTATATE (detectnet) dose/procedure
4 mCi, wait 45-90 mins, image from mid-thigh to skull base
cu64 dotatate half life and positron range
12.7 hours, short positron range = high-res images
