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PET Study Guide > chapter 2: pet rpxs > Flashcards

chapter 2: pet rpxs Flashcards

1
Q

c11 acetate moa

A

fatty acid that tracks the krebs cycle

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2
Q

c11 acetate use

A

myocardial oxygen consumption, fatty acid metabolism in oncology

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3
Q

c11 acetate production

A

reaction of grignard reagant, methyl magnesium bromide, co11 2 gas, purification

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4
Q

c11 acetate patient prep for oncology

A

fast for 6 hours

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5
Q

most common oncology applications for c11 acetate

A

mainly prostate, also brain tumors and hepatic cancer

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6
Q

c11 acetate dose for oncology

A

20 mCi

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7
Q

c11 acetate imaging procedure for oncology

A

dynamic image over area of interest, or wait 5 min and perform “body scan”

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8
Q

c11 acetate normal areas of uptake

A

NO uptake in the brain, NO excretion in urinary system

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9
Q

c11 choline moa

A

water-soluble nutrient transported into cells as a precursor for biosynthesis of phospholipids. represents fatty acid metabolism

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10
Q

c11 choline use

A

primarily prostate cancer, also brain and colon

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11
Q

c11 choline production

A

cyclotron produced, converted to c11 methyl iodide, reacted with dimethylethanolamine and purified

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12
Q

c11 choline procedure

A

6 hour fast, 20 mCi (same as c11 acetate), delay 5-10 mins and perform “body images”

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13
Q

f18 sodium fluoride use, production, dose, moa

A

exchanged with po4 ions with hydroxyapatite crystals in bone

10 mCi, delay 1-2 hours, total body imaging. may perform dynamic or blood pool

from cyclotron target, is captured on carbonate anion column, washed with water, eluted and formulated with sodium chloride

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14
Q

f18 fluciclovine brand name

A

axumin

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15
Q

f18 fluciclovine moa

A

amino acid transport

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16
Q

where does f18 fluciclovine localize?

A

liver, pancreas, lung, bone marrow, myocardium, small amount excreted in urine

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17
Q

f18 fluciclovine production

A

nucleophilic substitution, similar to fdg

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18
Q

f18 fluciclovine procedure

A

void 30-60 mins before imaging. 10 mCi, begin imaging NO LATER than 4 mins post inj, start at mid thigh to base of skull. takes 20-30 mins

19
Q

f18 fluoroestradiol brand name

A

cerianna

20
Q

f18 fluoroestradiol moa

A

analog of estradiol. estrogen receptor mediated for breast cancer (ONLY ER +)

21
Q

f18 fluoroestradiol production

A

nucleophilic substitution, provided as multidose vial from manufacturer

22
Q

f18 fluoroestradiol dose/procedure

A

3-6 mCi, inject SLOW over 1-2 mins, hydrate during uptake, delay 20-80 mins (most sites do 80 min), scan eye to thigh

23
Q

f18 PSMA piflufolastat brand name

A

pylarify

24
Q

f18 piflufolastat production

A

nucleophilic substitution, requires high-performance liquid chromatography (HPLC) purification

25
Q

f18 piflufolastat dose/procedure

A

8-10 mCi, delay 60-90 mins, void, scan mid-thigh to skull base. total scan time 12-40 mins

26
Q

ga68 PSMA-11 (gozeotide) production

A

generator eluate must be chelated

27
Q

ga68 PSMA-11 dose/procedure

A

3-7 mCi, delay 50-100 mins, void, scan from mid thigh to skull base

28
Q

rb82 chloride moa

A

potassium analog, active transport via the Na/K ATP pump in myocardium

29
Q

rb82 chloride production

A

Sr82 generator

30
Q

Sr82 half life

A

25.6 days

31
Q

n13 ammonia moa

A

trapped in myocardium by glutamic acid/glutamine reaction fixation of ammonia

32
Q

n13 ammonia production

A

irradiation of high-purity water containing 5% ethanol

33
Q

n13 ammonia dose/procedure

A

15 mCi, wait 2-3 mins and scan. perform stress 25-30 mins later

34
Q

f18 fluorodopa production

A

electrophilic substitution using a stannyl(tin) based precursor or a multistep nucleophilic method. cyclotron must produce F2 (fluorine gas) for electrophilic method or F- form for nucleophilic method

35
Q

f18 fluorodopa procedure

A

withhold medications for PD 12 hours prior, premedicate with 150 mg carbidopa 1 hour before injection. perform dynamic imaging to produce a Ki map

36
Q

f18 florbetapir (amyvid) dose and uptake time

A

10 mCi, 30-50 min

37
Q

f18 flutemetamol (vizamyl) dose and uptake time

A

5 mCi, 60-120 min

38
Q

f18 florbetaben (neuraceq) dose and uptake time

A

8 mCi, 45-180 min

39
Q

f18 flortaucipir (tauvid) production

A

nucleophilic radiofluorination of precursor AVV1622 followed by acid hydrolysis

40
Q

f18 flortaucipir procedure and dose

A

10 mCi, wait 80 mins and image. no special prep required

41
Q

normal areas of uptake for Ga68 DOTATATE/TOC/NOC

A

salivary glands, liver, spleen, pancreas, kidney, bladder

42
Q

ga68 dota dose/procedure

A

3-5 mCi, wait 60-90 mins, perform WB imaging. may do dynamic imaging

43
Q

cu64 DOTATATE (detectnet) dose/procedure

A

4 mCi, wait 45-90 mins, image from mid-thigh to skull base

44
Q

cu64 dotatate half life and positron range

A

12.7 hours, short positron range = high-res images

PET Study Guide (19 decks)

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