chapter 1: rpx production

Question 1

all pet cyclotron facilities must file a…for any rpxs that they produce

new drug certification
new drug application
pet drug certification
pet drug application

Answer 1

new drug application

Question 2

T/F: research pet rpxs can be produced without a NDA if under the Investigational New Drug or a Radioactive Drug Research Committee

Answer 2

true

Question 3

Sr82 half life

Answer 3

25 days

Question 4

ge68 half life

Answer 4

271 days

Question 5

ge68 decays by what to ga68?

beta decay
alpha decay
positron decay
positronium decay

Answer 5

positron decay

Question 6

ge68/ga68 generator is similar to what other type of generator/cyclotron?

Answer 6

mo99/tc99m generator

Question 7

a deuteron is

a neutron plus an electron
a proton plus an electron
two neutrons plus an electron
a proton plus a neutron

Answer 7

a proton plus a neutron

Question 8

most cyclotrons used to create pet rpxs are…

vacuum chambers
housed in concrete bunkers
positive ion cyclotrons
negative ion cyclotrons

Answer 8

negative ion cyclotrons

Question 9

what type of particle is most commonly accelerated in a negative ion cyclotron?

a hydrogen atom
a hydrogen atom plus a neutron
an electron
a hydrogen atom plus an electron

Answer 9

a hydrogen atom plus an electron

Question 10

what is the MeV range for negatively charged atoms accelerated in a pet cyclotron?

8-20
15-30
11-30
40-60

Answer 10

11-30 MeV

Question 11

c11 half life

Answer 11

20 min

Question 12

n13 half life

Answer 12

10 min

Question 13

o15 half life

Answer 13

2 min

Question 14

f18 half life

Answer 14

110 min

Question 15

which of these statements is NOT true regarding the advantages of negative ion vs positive ion cyclotrons?

negative ions cause much less nuclear activation of the cyclotron cavity and surroundings

negative ions are able to self focus the beam of particles

negative ions can irradiate two targets at one time

negative ion cyclotrons are smaller in size

Answer 15

negative ion cyclotrons are smaller in size

Question 16

which radionuclide is not a simple element used in biological processes in humans?

fluorine
carbon
nitrogen
oxygen

Answer 16

fluorine

Question 17

T/F: liquid filled targets are larger than gas filled targets

Answer 17

false

Question 18

irradiation time depends on everything except

particle size
probability of activating the target atoms
particle energy
beam current

Answer 18

particle size

Question 19

production of pet rpxs occurs with automated systems called

generators
cyclotrons
synthesis modules
production modules

Answer 19

synthesis modules

Question 20

the catalyst used for the production of f18 fdg is called

acetonitrile
mannose triflate
kryptofix 222
potassium carbonate

Answer 20

kryptofix 222

Question 21

f18 fdg must not have more than…of the f18 labeled amount in mCi per ml at time of calibration

95%
100%
110%
120%

Answer 21

110%

Question 22

test in which thin-layer chromatography is used to measure the Rf of f18 fdg to correspond to the reference standard

radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity

Answer 22

radiochemical identity

Question 23

test in which half-life is measured using a suitable radioactivity detector

radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity

Answer 23

radionuclidic identity

Question 24

test in which thin-layer chromatography radioactive Rf value corresponding to fdg is not less than 90% of total radioactivity of the chromatography plate

radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity

Answer 24

radiochemical purity

Question 25

test which ensures that the product contains > 99.5% of the radionuclide specified and is performed using a multichannel analyzer that demonstrates peaks only at 0.511 and 1.022 MeV radionuclidic identity radiochemical purity radiochemical identity radionuclidic purity

Answer 25

radionuclidic purity

Question 26

passing criteria for fdg requires that it does not contain more than...USP endotoxin units per maximum volume of injection 175 100 150 200

Answer 26

175

Question 27

what is the device used for testing radionuclidic purity? cutie pie dose calibrator gamma ray spectrometer positron spectrometer

Answer 27

gamma ray spectrometer

Question 28

this test is also known as the "bubble point test" sterility apyrogenicity chemical purity filter membrane integrity

Answer 28

filter membrane integrity

Question 29

the environment in which pet rpxs are dispensed must be an ISO class...clean room air-quality hood 1 2 3 4 5

Answer 29

5

Question 30

target material and nuclear reaction for F18-

Answer 30

H2O18 O18(p,n)F18-

Question 31

target material and nuclear reaction for F18^2

Answer 31

Ne20 Ne20(d,alpha)F18^2

Question 32

target material and nuclear reaction for N13

Answer 32

H2O16 O16(p,alpha)N13

Question 33

target material and nuclear reaction for C11

Answer 33

N14^2 N14(p,alpha)C11