chapter 1: rpx production Flashcards
all pet cyclotron facilities must file a…for any rpxs that they produce
new drug certification
new drug application
pet drug certification
pet drug application
new drug application
T/F: research pet rpxs can be produced without a NDA if under the Investigational New Drug or a Radioactive Drug Research Committee
true
Sr82 half life
25 days
ge68 half life
271 days
ge68 decays by what to ga68?
beta decay
alpha decay
positron decay
positronium decay
positron decay
ge68/ga68 generator is similar to what other type of generator/cyclotron?
mo99/tc99m generator
a deuteron is
a neutron plus an electron
a proton plus an electron
two neutrons plus an electron
a proton plus a neutron
a proton plus a neutron
most cyclotrons used to create pet rpxs are…
vacuum chambers
housed in concrete bunkers
positive ion cyclotrons
negative ion cyclotrons
negative ion cyclotrons
what type of particle is most commonly accelerated in a negative ion cyclotron?
a hydrogen atom
a hydrogen atom plus a neutron
an electron
a hydrogen atom plus an electron
a hydrogen atom plus an electron
what is the MeV range for negatively charged atoms accelerated in a pet cyclotron?
8-20
15-30
11-30
40-60
11-30 MeV
c11 half life
20 min
n13 half life
10 min
o15 half life
2 min
f18 half life
110 min
which of these statements is NOT true regarding the advantages of negative ion vs positive ion cyclotrons?
negative ions cause much less nuclear activation of the cyclotron cavity and surroundings
negative ions are able to self focus the beam of particles
negative ions can irradiate two targets at one time
negative ion cyclotrons are smaller in size
negative ion cyclotrons are smaller in size
which radionuclide is not a simple element used in biological processes in humans?
fluorine
carbon
nitrogen
oxygen
fluorine
T/F: liquid filled targets are larger than gas filled targets
false
irradiation time depends on everything except
particle size
probability of activating the target atoms
particle energy
beam current
particle size
production of pet rpxs occurs with automated systems called
generators
cyclotrons
synthesis modules
production modules
synthesis modules
the catalyst used for the production of f18 fdg is called
acetonitrile
mannose triflate
kryptofix 222
potassium carbonate
kryptofix 222
f18 fdg must not have more than…of the f18 labeled amount in mCi per ml at time of calibration
95%
100%
110%
120%
110%
test in which thin-layer chromatography is used to measure the Rf of f18 fdg to correspond to the reference standard
radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity
radiochemical identity
test in which half-life is measured using a suitable radioactivity detector
radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity
radionuclidic identity
test in which thin-layer chromatography radioactive Rf value corresponding to fdg is not less than 90% of total radioactivity of the chromatography plate
radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity
radiochemical purity
test which ensures that the product contains > 99.5% of the radionuclide specified and is performed using a multichannel analyzer that demonstrates peaks only at 0.511 and 1.022 MeV
radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity
radionuclidic purity
passing criteria for fdg requires that it does not contain more than…USP endotoxin units per maximum volume of injection
175
100
150
200
175
what is the device used for testing radionuclidic purity?
cutie pie
dose calibrator
gamma ray spectrometer
positron spectrometer
gamma ray spectrometer
this test is also known as the “bubble point test”
sterility
apyrogenicity
chemical purity
filter membrane integrity
filter membrane integrity
the environment in which pet rpxs are dispensed must be an ISO class…clean room air-quality hood
1
2
3
4
5
5
target material and nuclear reaction for F18-
H2O18
O18(p,n)F18-
target material and nuclear reaction for F18^2
Ne20
Ne20(d,alpha)F18^2
target material and nuclear reaction for N13
H2O16
O16(p,alpha)N13
target material and nuclear reaction for C11
N14^2
N14(p,alpha)C11
