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PET Study Guide > chapter 1: rpx production > Flashcards

chapter 1: rpx production Flashcards

1
Q

all pet cyclotron facilities must file a…for any rpxs that they produce

new drug certification
new drug application
pet drug certification
pet drug application

A

new drug application

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2
Q

T/F: research pet rpxs can be produced without a NDA if under the Investigational New Drug or a Radioactive Drug Research Committee

A

true

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3
Q

Sr82 half life

A

25 days

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4
Q

ge68 half life

A

271 days

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5
Q

ge68 decays by what to ga68?

beta decay
alpha decay
positron decay
positronium decay

A

positron decay

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6
Q

ge68/ga68 generator is similar to what other type of generator/cyclotron?

A

mo99/tc99m generator

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7
Q

a deuteron is

a neutron plus an electron
a proton plus an electron
two neutrons plus an electron
a proton plus a neutron

A

a proton plus a neutron

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8
Q

most cyclotrons used to create pet rpxs are…

vacuum chambers
housed in concrete bunkers
positive ion cyclotrons
negative ion cyclotrons

A

negative ion cyclotrons

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9
Q

what type of particle is most commonly accelerated in a negative ion cyclotron?

a hydrogen atom
a hydrogen atom plus a neutron
an electron
a hydrogen atom plus an electron

A

a hydrogen atom plus an electron

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10
Q

what is the MeV range for negatively charged atoms accelerated in a pet cyclotron?

8-20
15-30
11-30
40-60

A

11-30 MeV

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11
Q

c11 half life

A

20 min

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12
Q

n13 half life

A

10 min

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13
Q

o15 half life

A

2 min

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14
Q

f18 half life

A

110 min

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15
Q

which of these statements is NOT true regarding the advantages of negative ion vs positive ion cyclotrons?

negative ions cause much less nuclear activation of the cyclotron cavity and surroundings

negative ions are able to self focus the beam of particles

negative ions can irradiate two targets at one time

negative ion cyclotrons are smaller in size

A

negative ion cyclotrons are smaller in size

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16
Q

which radionuclide is not a simple element used in biological processes in humans?

fluorine
carbon
nitrogen
oxygen

A

fluorine

17
Q

T/F: liquid filled targets are larger than gas filled targets

A

false

18
Q

irradiation time depends on everything except

particle size
probability of activating the target atoms
particle energy
beam current

A

particle size

19
Q

production of pet rpxs occurs with automated systems called

generators
cyclotrons
synthesis modules
production modules

A

synthesis modules

20
Q

the catalyst used for the production of f18 fdg is called

acetonitrile
mannose triflate
kryptofix 222
potassium carbonate

A

kryptofix 222

21
Q

f18 fdg must not have more than…of the f18 labeled amount in mCi per ml at time of calibration

95%
100%
110%
120%

A

110%

22
Q

test in which thin-layer chromatography is used to measure the Rf of f18 fdg to correspond to the reference standard

radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity

A

radiochemical identity

23
Q

test in which half-life is measured using a suitable radioactivity detector

radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity

A

radionuclidic identity

24
Q

test in which thin-layer chromatography radioactive Rf value corresponding to fdg is not less than 90% of total radioactivity of the chromatography plate

radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity

A

radiochemical purity

25
Q

test which ensures that the product contains > 99.5% of the radionuclide specified and is performed using a multichannel analyzer that demonstrates peaks only at 0.511 and 1.022 MeV

radionuclidic identity
radiochemical purity
radiochemical identity
radionuclidic purity

A

radionuclidic purity

26
Q

passing criteria for fdg requires that it does not contain more than…USP endotoxin units per maximum volume of injection

175
100
150
200

A

175

27
Q

what is the device used for testing radionuclidic purity?

cutie pie
dose calibrator
gamma ray spectrometer
positron spectrometer

A

gamma ray spectrometer

28
Q

this test is also known as the “bubble point test”

sterility
apyrogenicity
chemical purity
filter membrane integrity

A

filter membrane integrity

29
Q

the environment in which pet rpxs are dispensed must be an ISO class…clean room air-quality hood

1
2
3
4
5

A

5

30
Q

target material and nuclear reaction for F18-

A

H2O18

O18(p,n)F18-

31
Q

target material and nuclear reaction for F18^2

A

Ne20

Ne20(d,alpha)F18^2

32
Q

target material and nuclear reaction for N13

A

H2O16

O16(p,alpha)N13

33
Q

target material and nuclear reaction for C11

A

N14^2

N14(p,alpha)C11

PET Study Guide (19 decks)

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