Chapter 17: Oral Manifestations of Systemic Diseases Flashcards
___ is characterized by excess bilirubin in the bloodstream that accumulates in the tissues, which results in a yellowish discoloration of the skin and mucosa
jaundice
what are the causes of jaundice?
numerous causes; some are physiologic, many are pathologic
___ is an inherited, innocuous problem seen in 5% of americans and is characterized by impaired processing of bilirubin by the liver
gilbert syndrome
other than gilbert syndrome, what are 3 other causes of jaundice?
- sickle cell anemia
- liver infections or toxins
- cancer
___ fibers have an affinity for bilirubin, so what areas are more prominently affected?
- elastin fibers
- sclera, lingual frenum, soft palate
what are some signs and symptoms due to hyperbilirubinemia that may occur with jaundice?
fever, abdominal pain, anorexia, fatigue
patients with jaundice should be evaluated for ___
undelrying condition
what is the prognosis of patients with jaundice?
depends on the etiology of the jaundice
jaundice
___ is a group of conditions characterized by the deposition of an extracellular, proteinaceous substance that gives the condition its name
amyloidosis
(amyloid is the extracellular, proteinaceous substance)
what are the classifications of amyloidosis?
- organ-limited
- systemic
- primary
- myeloma associated
- secondary
- hemodialysis associated
- heredofamilial
which classification of amyloidosis can occur in a variety of organs, but is rarely seen in the oral cavity, and has no association with any systemic condition?
organ-limited amyloidosis
what is an example of organ-limited amyloidosis?
amyloid nodule, which is a solitary, asymptomatic, submucosal deposit
which classifications of amyloidosis affect older adults, has a male predominance, with initial signs that are nonspecific but eventually develop carpal tunnel syndrome, mucocutaneous lesions, hepatomegaly, and macroglossia?
primary and myeloma-associated systemic amyloidosis
20% of primary and myeloma-associated systemic amyloidosis cases are due to ___
multiple myeloma
describe skin lesions associated with primary and myeloma-associated systemic amyloidosis
appear as smooth-surfaced, firm, waxy papules and plaques
what are the most commonly affected areas in primary and myeloma-associated systemic amyloidosis?
eyelid, neck, and lips
which classification of amyloidosis develops as a result of a chronic inflammatory process, such as TB, sarcoidosis, or osteomyelitis?
secondary systemic amyloidosis
what organs are affected by secondary systemic amyloidosis?
the heart is spared, but it affects the liver, kidney, and spleen
is secondary systemic amyloidosis common? why or why not?
not common after advent of modern antibiotic therapy
which classification of amyloidosis is characterized by an accumulation of protein in plasma (as a result of not being removed by dialysis), which eventually deposits in the bones and joints?
hemodialysis-associated systemic amyloidosis
which classification of amyloidosis is uncommon but a significant form of the disease, is autosomal dominant, and patients have polyneuropathies primarily
heredofamilial systemic amyloidosis
what are other conditions associated with heredofamilial systemic amyloidosis?
cardiomyopathy, cardiac arrhythmias, congestive heart failure, and renal failure develops as the condition progresses
what is the treatment for amyloidosis?
in most instances, no effective therapy is available
most patients with systemic amyloidosis succomb to ___, ___, or ___ within months to a few years after diagnosis
cardiac failure, arrhythmia, or renal disease
amyloidosis
are significant vitamin deficiencies common in the US?
no
what patients are commonly affected by vitamin deficiencies?
patients with malabsorption syndromes or eating disorders, those following “fad diets”, and alcoholics
describe vitamin A deficiency
- vitamin A = retinol
- essential for vision
- may lead to blindness
describe vitamin B1
- vitamin B1 = thiamin
- maintain proper functioning of neurons
- beriberi
describe vitamin B2
- aka riboflavin
- necessary for cellular oxidation-reduction reactions
- oral alterations like angular cheilitis, glossitis
describe vitamin B3
- aka niacin
- acts as a coenxyme for oxidation-reduction reactions
- pellagra (shown) = dermatitis, dementia, diarrhea
describe vitamin B6
- aka pyridoxine
- cofactor associated with enxymes that participate in amino acid synthesis