Chapter 16 Development, Stem Cells And Cancer Flashcards
Cell specialization
The process by which cells become specialized in structure and function
The physical processes that give an organism its shape constitute
Morphogenesis
Differential gene expression results from genes being regulated
Differently in each cell type
Cytoplasmic Determinants
Are material substances in the egg that influence early development
Induction
Signal molecules from embryonic cells cause transcriptional changes in nearby target cells
Determination
Commits a cell irreversibly to its final fate
Apoptosis
Programmed cell death
Pattern Formation
Is the development of a spatial organization of tissues and organs
Positional Information
The molecule cues that control pattern formation, tells a cell its location relative to the body axis and to neighboring cells
Homeotic Genes
Control pattern formation in late embryo larva and adult stages
Embryonic Lethals
Causing cell death during embryogenesis
Maternal effect genes
Encode cytoplasmic determinate that initially establish the axis of the body of drosophila
Bicoid
Maternal effect gene that Affects the front half of the body
Morphogens
Substances that establish an embryos axes and other features
Totipotent
Cells that can give rise to all the specialized cell types in the organism
In cloning of animals, the _______ of an unfertilized egg or zygote is replaces with the ________ of a differentiated cell called ________
Nucleus, nucleus, nuclear transplantation
A stem cell is a
Relatively unspecialized cell that can reproduce itself indefinitely and differentiate into specialized cells of one or more types
Pluripotent
Stem cells that are able to differentiate into any cell type
Oncogenes
Cancer causing genes
Protooncogenes
Normal version of oncogenes that code for proteins that stimulate normal cell growth and division
Tumor suppressor genes
Encode proteins that help prevent uncontrolled cell growth
Mutations in the _____ and the ______ ate common in human cancers
Ras proto-oncogene, p53 tumor-suppressor gene
Mutations in the ______ p53 gene prevent
Suppression of the cell cycle
DNA ______ can contribute to cancer
Breakage
Viruses play a role in a cancer by
Donating an oncogene
Model Organisms
Organisms that are non human and are studied as a proxy to understand human biology