Chapter 12 & 13 Flashcards
blank is not in the z line because blank anchors it to the z line
myosin, titin
contractile functional proteins
actin and myosin
blank cover active site on blank to prevent blank heads from binding
troponin/tropomyosin, actin, myosin
force created by muscle
muscle tension
creation of tension
contraction
release of tension
relaxation
weight opposing contraction
load
blank is physically linked to blank
DHP, RyR
state when the myosin head is bound to the actin with no ADP or ATP to be found
rigor state
rigor state is the most blank state
stable
blank is needed to get the myosin out of the rigor state in the blank phase
ATP, relaxation
on muscle contraction there is not really much of a blank
hyperpolarization
longest electrical event in contraction
muscle twitch
three electrical events in contraction
neuron AP, muscle AP, muscle twitch
speed tension in muscle fiber is determined by
speed of myosin binding ATP and letting it go
max tension in muscle fiber is determined by
number of myosin crossbridges formed
twitch duration of muscle fiber is determined by
more calcium pumps and faster they work the shorter the twitch duration
blank creatine kinase is different than blank creatine kinase
cardiac, skeletal
two types of fatigue
central, peripheral
fatigue when the muscle can no longer respond to signal
peripheral
fatigue when signal cannot be sent to muscle
central
central fatigue is a blank function
protective
extended submaximal exercise results in blank which causes fatigue
decreased glycogen stores
short duration maximal exertion does what in cytosol to cause fatigue
increases inorganic phosphate
increasing phosphate is negative so it binds blank and blanks levels of calcium
calcium, decreases
Two structural proteins in muscles
Titin and nebulin
Structural protein that anchors myosin to z line and provides elasticity
Titin
Structural protein that provides structure for actin
Nebulin
Regulatory proteins in muscles
Troponin and tropomyosin
Troponin and tropomyosin bind blank and blank active sites
Ca ions, cover
extended maximal exercise fatigue is caused by
increased K+ in ECF of t tubules and increase of H+ in ICF
muscle fibers powered by glycolysis
glycolytic
muscle fibers powered by oxidative phosphorylation
oxidative
three types of skeletal muscle fibers
slow twitch oxidative red, fast twitch oxidative glycolytic red, fast twitch glycolytic white
fastest muscle fiber
fast twitch glycolytic white because only uses glycolysis
skeletal muscle fiber requiring most blood supply
slow twitch oxidative red
this stores oxygen in muscles kind of like hemoglobin
myoglobin
muscles that are really only used for posture
slow twitch oxidative red
muscle fibers that are developed as endurance runner
fast twitch oxidative glycolytic red
occurs if the muscle is told to contract twice before it can relax after the first one
summation
blank tetanus is when there is still a small relaxation period but it is at max tension
unfused
blank tetanus is when there is no relaxation during max tension of muscle
fused
two ways to increase tension
mechanical summation, recruitment
stimulate same motor units at higher frequency way to increase tension
mechanical summation
increase stimulation to exceed threshold in more motor units way to increase tension
recruitment
biggest motor units cannot be blank
consciously recruited
muscle disorder called overuse is blank
tearing connective tissue or muscle fibers
repairing from overuse is done by blank
hypertrophy
disuse and atrophy of muscles leads to decreased blank , blank, and blank
enzymes, blood supply, contractile proteins
inherited muscle disorder that causes myophosphorylase deficiency which leads to no glycogenolysis
mcardle’s disease
mcardle’s disease affects which muscle fiber
glycolytic white
this is inherited muscle disorder where one is lacking dystrophin
Duchenne’s muscular dystrophy
anchors actin to cell membrane
dystrophin
most common type of smooth muscle and acts as one due to blank
single unit, gap junctions
ICF full of calcium ions causes contractile force in blank smooth muscle
single unit
contractile force in this type of smooth muscle is caused by recruitment
multi unit
uterus has blank smooth muscle for birth and blank smooth muscle for menstruation
single unit, multi unit
contraction and relaxation of smooth muscle is blank than striated and maintains force for blank periods
slower, longer
smooth muscle is not controlled by blank, it is blank
troponin-tropomyosin, enzyme regulation
there are no blank in smooth muscles
sarcomeres
smooth muscle has less blank than skeletal muscle
sarcoplasmic reticulum
cyclical exceed of threshold and is always on but changes rates like tonic control
pacemaker
chemical signals can also cause blank rather than blank stimulus
contraction, electrical
changing enzyme activity without ion movement can be done via blank rather than blank in smooth muscle causing more blank without changing blank
transduction, signaling, muscle tension, membrane potential
with higher levels of blank, more myosin crossbridges will be formed to increase blank
MLCK, muscle tension
increasing blank will cause more myosin crossbridges to be blank in smooth muscle
myosin phosphatase, broken
beta blank receptors are involved in blank control
autonomic
three ways to regulate smooth muscles
modification of Ca ions in ICF, ANS, hormones
cardiac muscle is unique because it shares some aspects of blank and blank
smooth, skeletal
cardiac muscle is blank and has blank structure like skeletal muscle
striated, sarcomere
cardiac muscle is regulated by blank like skeletal muscle
troponin-tropomyosin
cardiac muscle fibers are unlike skeletal because muscle fibers are blank with blank nucleus and does not have blank physically linked to blank
shorter, one, DHP, RYR
cardiac muscle is like smooth because it has blank synapses and exhibit blank potentials
electrical, pacemaker
cardiac muscle is like smooth muscle because it is under blank and blank control
hormonal, autonomic
three types of proprioceptors
golgi tendon organs, muscle spindles, joint receptors
golgi tendon organs regulate blank
isometric tension
muscle spindles regulate blank
stretch
joint receptors regulate blank
positiion
skeletal muscle reflexes synapse onto first order blank neuron usually into blank tracts
sensory, spinocerebellar
CNS integrates blank signal in a skeletal muscle reflex
input
blank motor neurons carry output signal in a skeletal muscle reflex
somatic alpha
alpha motor neuron carries skeletal muscle reflex to blank fibers
skeletal muscle
these skeletal muscle fibers go from origin to the insertion
extrafusal fibers (alpha motor neurons)
muscle spindles that span from origin or insertion to the middle muscle spindles, not from origin to insertion
intrafusal fibers
the ends are blank in intrafusal fibers but the central region is blank
contractile, not (sensory)
these motor neurons innervate intrafusal fibers
gamma
gamma motor units increase blank in spindle
tension
gamma motor neurons are blank sensitive to stretch
more
when extrafusals contract, intrafusals increase blank to stay sensitive to stretch
tension
if gamma is not used then the amount of blank input goes blank
sensory, down
sensory and somatic neurons are usually linked by blank
interneurons
sensory and somatic neurons can cause blank or blank
inhibition, excitation
all pathways controlling a single joint =
myotatic unit
this prevents antagonistic muscles from opposing action
reciprocal inhibition
spinal cord integrates spinal reflexes and contains blank for rhythmic movements
central pattern generators
rhythmic movements are initiated and terminated by blank
cerebral cortex