Chapter 10 (Muscular Tissue VII) Flashcards
Neuromuscular junction (NMJ)
Motor neurons have a threadlike axon that extends from the brain or spinal cord to a group of muscle fibers
Action potentials arise at the interface of the motor neuron and muscle fiber
Synapse
Where communication occurs between a somatic motor neuron and a muscle fiber
Synaptic cleft
Gap that separates the two cells
Neurotransmitter
Chemical released by the initial cell communicating with the second cell
Synaptic vesicles
Sacs suspended within the synaptic end bulb containing molecules of the neurotransmitter acetylcholine (Ach)
Motor end plate
The region of the muscle cell membrane opposite the synaptic end bulbs
Contain acetylcholine receptors
Nerve impulses elicit a muscle action potential:
Release of acetylcholine
Activation of ACh receptors
Production of muscle action potential
Termination of ACh activity
Release of acetylcholine
Nerve impulse arriving at the synaptic end bulbs causes many synaptic vesicles to release ACh into the synaptic cleft
Activation of ACh receptors
Binding of ACh to the receptor on the motor end plate opens an ion channel
Allows flow of Na+ to the inside of the muscle cell
Production of muscle action potential
The inflow of Na+ makes the inside of the muscle fiber more positively charged triggering a muscle action potential
The muscle action potential then propagates to the SR to release its stored Ca++
Termination of ACh activity
Ach effects last only briefly because it is rapidly broken down by acetylcholinesterase (AChE)