Chap 6 Flashcards

1
Q

What is a hormone?

A

Is the mediator molecule released in the whole body from endocrine glands to specific receptors

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2
Q

What do exocrine glands do?

A

Secrete their products into ducts carrying secretions into body cavities (e.g., digestive enzymes)

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3
Q

What do endocrine glands do?

A

Release hormones into the interstitial fluid. Hormones then diffuse into bloodstream (e.g., pituitary gland

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4
Q

List some exocrine glands

A

Salivary glands that secrete saliva into the mouth
Bile-producing glands of the liver
Prostate gland
The portion of the pancreas that secretes pancreatic fluid into the duodenum
Gastric glands
Sweat glands

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5
Q

What are primary endocrine glands in CNS

A

Hypothalamus
Pituitary gland
Pineal gland

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6
Q

Primary Endocrine glands outside of CNS

A
Thyroid gland
Parathyroid gland
Thymus
Adrenal gland
Pancreas
Gonads (ovaries and testes)
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7
Q

Secondary endocrine glands

A
Kidneys
Stomach
Liver
Small intestine
Skin
Heart
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8
Q

What are the targets of hormones

A

glycoprotein receptors

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9
Q

What two mechanisms regulate the number of cell receptors?

A

Down-regulation (suppression)

Up-regulation (sensitivity increase)

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10
Q

How do circulating hormones move?

A

use bloodstream as a vehicle to reach their cell targets

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11
Q

What do local hormones do? Give two examples.

A

act on their surrounding cells or on themselves

Paracrines, act on nearby cell. Autocrine, act on self

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12
Q

How do water soluble hormones circulate

A

circulate in a free form in blood

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13
Q

Lipid soluble hormones circulate how?

A

need a vehicle (transport proteins) to reach the target cells

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14
Q

What three functions do transport proteins have?

A

Make LSH temporally WSH
Delay the filtering mechanism
Provide a LSH reserve in bloodstream

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15
Q

What are the two classes of hormones?

A

Lipid soluble and water soluble

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16
Q

Three types of lipid soluble hormones and how they are derived.

A

Steroid hormones derived from cholesterol
Thyroid hormones synthesized from iodine and AA tyrosine
Nitric Oxide (NO) catalyzed by NO-synthase

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17
Q

LSH mechanisms of action (4)

A

A free LSH diffuses from the blood through the cell
LSH binds and activates the receptor within cytosol or nucleus which in turn will alter gene expression
From this, new proteins are built
These new proteins will trigger an increase or a decrease in LSH level into the cell

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18
Q

WSH mechanisms of action (6)

A

WSH diffuses from blood to external cell layer and binds with receptor
Adenylyl cyclase converts ATP to cAMP
cAMP serves as second messager to activate protein kinase
Protein kinase phosphorylates other enzymes
This produces million of biochemical reactions
After brief period, cAMP is desactivated

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19
Q

The responsiveness of a target cell to a specific hormone depends on

A

Hormone concentration
Number of cell receptors
Influence of antagonist hormones

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20
Q

Hormone secretion is regulated by

A

Signals from Nervous System
Chemical changes in blood
Influence of antagonist hormones

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21
Q

Hypothalamus is interface between what?

A

Nervous system and endocrine system

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22
Q

Hypothalamus Influenced by what?

A

Pain, stress, emotion

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23
Q

Hypothalamus controls what?

A

ANS, body temperature, thirst, hunger, sex,

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24
Q

Hypothalamus synthesizes how many hormones?

A

9

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25
What does anterior pituitary gland do
secretes hormones regulating a wide range of bodily activities
26
What does posterior pituitary gland do?
contains axons and axon terminals (10 000 neurons) related to the hypothalamus
27
Neurosecretary cells from hypothalamus have 5 what and 2 what
5 releasing hormones that stimulate secretion and two releasing hormones that decrease secretion
28
Human growth hormone released from? Main function? What are the target cells? Released where?
Anterior pituitary. stimulate synthesis and secretion of Insulin growth factors. Target cells are liver, skeltal muscle cartlidge and bone. released in blood stream or acts locally
29
What are some IGF functions?
Increase uptake of AA by cells,decrease AA breakdown, use AA as a substrate for ATP, enhance lypolysis, decrease glucose uptake,
30
IGF and hGF stimulate release of?
Liver glucose
31
What do somatotrophs do?
Release hGH every few hours mainly during sleep
32
What does Growth hormone-releasing hormone do
Promotes secretions of hGH
33
What does Growth hormone-inhibiting hormone do
Supresses secretions of hGH
34
what is major regulator of GHRH and GHIH?
blood glucose level
35
High blood glucose stim release of? Low blood glucose?
GHIH, GHRH
36
What does TRH do?
Controls TSH release from hypothalamus
37
What does TSH do
Stimulates T3 and T4 both in thyroid gland
38
What do T3 and T4 hormones do?
Inhibit TRH(feedback loop)
39
How is foccile-stimulating hormone strimulated?
When hypothalamus releases GnRH
40
FSH stimulates what
Follicular cells to secrete estrogen, sperm producton and development of several ovarian follicles
41
GnRH and FSH are inhibited by
estrogens and testosterones
42
H is stimulated by ?
GnRH
43
LH triggers what? (3)
ovulation, estrogens, and stimulation of interstitial cells in the testes to secrete testosterones
44
what do estrogens and progesterone do?
prepare for fertilizing mechanisms and milk secretion
45
What does prolactin hormone do?
Initiates and maintains lactation
46
Coticotroph cells secrete what?
ACTH
47
what does ACTH do
Controls secretion of cortisol and glucocorticoids
48
Increased released ACTH how >
stress
49
posterior pituitary also called
neurohypophysis
50
Posterior Pit. doesnt do what? What does it do? Relies on what?
Doesn't synthesize hormones, stores and releases oxytocin and ADH. Hypothalamus
51
Oxytocin serves mainly as? Stimulates what? involved in what?
Smooth muscle stimulator. Milk ejection, sexual pleasure.
52
ADH regulates fluid balance by?
Decreasing urine volume, decreasing sweat water loss, increasing blood pressure
53
What regulates ADH secretion
blood osmotic pressure and blood volume
54
Thyroid gland releases what?
T3 and T4 and CT
55
Stores T3 and T4 in small or large quantity?
Large.
56
T3 and T4 formed where, CT formed where?
Follicular, and parafollicular
57
T3 and T4 hormones do what?
``` Increase BMR stimulate protein synthesis Increase glucose and FA uptake for ATP production Increase lipolysis Enhance cholesterol excretion Accelerate body growth Contribute to CNS development ```
58
CT in involved in what
regulation of Ca2+ and phosphates
59
CT secretion is controlled by ?
Feedback loop
60
What does the parathyroid gland involve?
Ca2+ regulation and Mg2+ regulation
61
Adrenal gland is subdivided into what?
Adrenal cortex: 80-90% of the gland, and adrenal medulla which is centrally located
62
Adrenal cortex divided into 3 zones
Glomerulosa, fasciculata, and reticularis
63
What does each zone of adrenal cortex do
Glomerulosa- Secretes aldosterone, Fasciculata- secretes cortisol, corticosterone and cortisone(increase prot. breakdown. Reticularis- secretes DHEA(growth and sexual functions)
64
Glucocorticoids and effects
Protein breakdown Glucose formation Lipolysis Resistance to stress Anti-inflammatory effects Depression of immune system
65
Adrenal Medulla secrete two hormones
Epinephrine =80% of secreted hormones, norepinephrine=20% of secreted hormones
66
Pancreas endocrine or exocrine functions?
Both
67
Pancreatic cells arranged in clusters called? produce what?
Acini-produce digestive enzymes
68
Four types of hormones that pancreas secretes
Alpha cells, Beta cells, Delta cells, F cells
69
What do alpha cells do?
Secrete glucagon, raise glucose level
70
What do beta cells do?
Secrete insulin, lower glucose
71
What do delta cells do?
Secrete somatostatin, inhibit glucagon and insulin
72
what do F cells do?
Secrete polypeptide, inhibit somatostatin and digestive enzymes
73
What is the most important stimulator of inisulin?is that the only stimulator?
Glucose level. No many others
74
What else will stim release of glucagon?
Sympathetic activity (ANS) and a rise in blood AA parallel with low glucose
75
Ovaries produce what?
Produce estrogens, progesterone, FSH and relaxin
76
What does the pineal gland function as?
Secretes melatonin
77
What does melatonin do?
inhibits reproductive functions in animals
78
General adaptation syndrom caused by what? Results in what?
stressful conditions, Homeostasis disrupton
79
fight or flight response initiated by what ?
Hypothalammus through SNS
80
What does flight or fight response do?
Brings huge amounts of O2 and glucose to brain muscle and heart, inhibits other organ functions
81
What is the resistance reaction?
Allows to continue fighting a stressor long after fight or flight dissapeared