CH27 Antimicrobial Therapy Flashcards
antibiotics that taget cell wall synthesis hint: PCBV
-peniccillin
-cephalosporin
-bacitracin
-vancomycin
antibiotics that target protein synthesis hint: CTAML
-chloramphenicol
-tetracyclines
-aminoglycosides
-macrolides
-lincosamides
antibiotics that target cell membrane hint: PDAI
-polymyxin
-daptomycin
-amphotericin
-imidazoles (vs fungi)
antibiotics that target nucleic acid function Hint: NNQR
-nitroimidazoles
-nitrofurans
-quinolones
-rifampin
antibiotics that target intermediary metabolism hint: ST
-sulfonamides
-trimethoprim
if you have resistance to vancomycin what should you use?
teixobectin
what are the two penicillin strains capable of gram-negative bacterial treatment
-methicillin
-carbencillin (pseudomonas infections)
synthetic protein synthesis antibacterial that only hits gram-positive bacteria is called what? and why does it only hit gram-positive bacteria?
F. Linezolid
- only gram positive because of eflux pumps
when the agar plate has mucoid colonies what does that tell you?
there is a lot of capsule production
what does ESKAPE stand for
ESKAPE is an acronym for a group of bacteria that are highly dangerous and deadly
- ESKAPE stands for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species
what antiviral drug inhibits the M2 protein and fights influenza virus
amantadine (prevents viral uncoating)
what antiviral drug is used to fight H1N1
tamiflu (neuraminidase inhibitor)
what antiviral drug is a guanosine analog
acyclovir
what antiviral drug is absorbed 80% and fights herpes
famciclovir
what is a prodrug
a biologically inactive compound which can be metabolized in the body to produce a drug.
what antiviral drug is used to fight HIV
AZT (inhibits reverse transcriptase)
what is an antifungal that turns you purple
gentian violet
- used to treat fungus infections inside the mouth (thrush) and of the skin.
if there is no oh group on the nucleotide (deoxy) then what happens to the nucleotide
is the 3’ OH group is absent then there wont be addition of new nucleotides in the polynucleotide chain (the rxn would stop)
what are dNTPs (deoxynucleotides)
The substrates for DNA polymerizing enzymes
video for sangers DNA sequencing method
https://www.youtube.com/watch?v=KTstRrDTmWI
what does deep-branching mean
bacteria that appear to have diverged the earliest from ancestral archaea and eukaryotes
