Ch.20: Antimicrobial Drugs

Question 1

Act by killing or by interfering with the growth of microorganisms. Must often act within the host without damaging the host. SELECTIVE TOXICITY

Answer 1

antimicrobial drugs

Question 2

a substance produced by microorganisms that in small amounts inhibit other microorganisms

Answer 2

antibiotic

Question 3

Some drugs have a _____ ______ __ _______ ______, or range of different microbial types that they affect.

Answer 3

narrow spectrum of microbial activity

Question 4

A primary factor involved in the selective toxicity of antibacterial actions lies in the

Answer 4

lipopolysacchride outer layer of gram negative bacteria, peptidoglycan and the porins

Question 5

Five modes of action of antimicrobial drugs inlcude

Answer 5

inhibiting cell wall synthesis
inhibiting protein synthesis
injuring the plasma membrane
inhibiting nucleic acid synthesis
inhibiting the synthesis of essential metabolites

Question 6

True Or False: Antimicrobial drugs usually must target microbial structures or function that ARE shared with mammalian structures or functions.

Answer 6

FALSE: THEY TARGET ONES THAT ARE NOT SHARED.

Question 7

Antibacterial Drugs Targets:

Answer 7

peptidoglycan of the cell wall
70s ribosomes
plasma membrane

Question 8

Antifungal Drugs Target:

Answer 8

ergosterols in the plasma membrane

cell wall CHITIN (glucan)

Question 9

Antiprotozoan Drugs Targets:

Answer 9

target specific characteristics for the different types of protozoa. MORE TOXIC

Question 10

Antihelminthic Drugs Target:

Answer 10

Inhibition of ATP production

Alters permeability of the plasma membrane