ch.15 Flashcards
What are the three main lines of defense?
physical barriers, internal, and immune response
physical barriers
skin, mucus membranes
internal defenses
protective cells, blood-borne chemicals,
lysozyme
found in saliva and tears, act against cell wall of bacteria, first line of defense
complements
set of serum proteins that can trigger inflammation and fever
-MAC attack
innate immunity
present at birth
adaptive immunity
responds to specific pathogens
What processes are included in the second line of defense?
phagocytosis, extracellular killing by leukocytes, nonspecific chemical defenses, inflammation, fever
phagocytosis
ingestion of bacteria
-chemotaxis, adhesion, ingestion,maturation, killing, elimination
phagocytosis
ingestion of bacteria
-chemotaxis, adhesion, ingestion, maturation, killing, elimination
chemotaxis
migration of a cell in response to a chemical stimulus
defense components of blood
leukocytes are defensive blood cells
granuolocytes
neutrophils, eosinophils, basophils
Defense Components of neutrophils and eosinophils
capable of diapedesis or passage of blood through capillaries, also perform phagocytosis of pathogens
also, perform extracellular killing
Defense Components of basophils
do not phagocytize and release inflammatory chemicals
Who performs extracellular killing?
eosinophils, NK cells, and neutrophils
How do eosinophils perform extracellular killing?
bind to a parasitic worm’s surface and secrete protein toxins to weaken or kill the worm
How do natural killers perform extracellular killing?
secrete protein toxins onto surfaces of virally infected cells and tumors
neutrophils
can kill nearby invaders with chemicals found in cytoplasmic membranes
inflammation
general response to tissue damage
acute inflammation
develops quickly, typically beneficial, results in the elimination or resolution of condition
-results in dilate blood vessels and tissue repair
chronic inflammation
develops slowly, lasts a long time, and can damage or kill tissues to result in disease
tissue repair
the final stage of inflammation
delivers oxygen and extra nutrients to the inflamed site
areas such as skin and mucus membrane repair rapidly
fever
body temp over at 37C
hypothalamus
controls the bodys internal temp
What effect does the hypothalamus have on temp?
controls the body internal temp
pyrogens
trigger the hypothalamus to increase the body temp