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Dermatology Mayo > Ch 9 Bullous Diseases > Flashcards

Ch 9 Bullous Diseases Flashcards

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Dermatology Board Prep flashcards
1
Q

Subcorneal Bullous Diseases

A

-SSS, Impetigo, Miliaria

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2
Q

Intraepidermal

A
  • Viral/Herpes
  • Pemphigus Vulgaris
  • Acute Eczema
  • Miliaria Rubra
  • Incontentia Pigmentii
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3
Q

Subdermal

A
  • Bullous Pemphigoid
  • Linear IgA
  • Dermatitis Herpetiformis
  • Bullous LE
  • Cicatrical Pemphigoid
  • Bullous EM
  • PCT
  • TEN
  • EB
  • Other bullous diseases
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4
Q

Pemphigus Vulgaris types

A
  • Pemphigus Vulgaris
  • Pemphigus Vegitans (folds, heaped up, less serious)
  • Desmoglein 3
  • HLA-2, Indian, Jews, Meds
  • More severe
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5
Q

Superficial Pemphigus

A
  • Generalized Foliaceous
  • Localized erythematous
  • Desmoglein 1
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6
Q

Drug Induced

A

-Penicillamine no Ab

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7
Q

Paraneoplastic

A
  • Thymoma
  • Castelmans
  • Lymphoma
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8
Q

Pemphigus Vulgaris

A
  • Mucous Membrane Involvment
  • Desmoglein 3
  • Serum Ab
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9
Q

Pemphigus Vulgaris Treatment

A

-High Dose steroids increase desomogleins and decrease Ab

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10
Q

Subcorneal Pustular Dermaotosis

A

often IgA to intercellular Ag

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11
Q

Transient Acantholytic Dermatitis (Grover’s)

A

-Itchy vesicles in sun damaged skin
-Acantholysis
Middle aged men

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12
Q

Bullous Pemphigoid Cause

A
  • Subepidermal blister
  • Ab to BP-230 (hemi to keratin)
  • BP-180 (hemi to LL)
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13
Q

BP Histology

A

-IgG and C3 at BM

Eospinphils

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14
Q

BP Presentation

A

-Elderly with itchy tense blood filled vesicles common on flexures

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15
Q

BP Tx

A
  • Minimal steroids, can use topical

- Tetracyclins, Niacin

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16
Q

Herpes Gestationalis

A

-Linear C3 at BM with minimal Ig

17
Q

Linear IgA

A
  • IgA at BM with C3

- Tx with dapsone

18
Q

Cicatrical Pemphigoid

A
  • Lesions generally occur only on the eyes and mucous membranes, minimal skin involvment
  • Ab to laminin 5
19
Q

Dermatitis Herpetiformis

A

IgA and C3 at BM

  • Treat with Dapsone
  • Bx both lesional and non lesional skin
  • Itchy vesicles on extensors and buttocks
  • Check G6PD
  • HLADR3, DQW2
20
Q

Other subepi

A

DM related

  • Bullous LE
  • PCT
  • Most others
21
Q

TEN

A

-Drugs: Sulpha, Siezures, allopurinaol, GVHD, AIDS

22
Q

EB Simplex

A
  • AD to Keratin 5/14

- Blisters occur above basal layer leading to minimal scarring an intraepidermal lysis

23
Q

Junctional EB

A
  • AR to lamina lucidum/BP180

- Rare, deadly early

24
Q

Dystrophic EB

A
  • Mutations in collagen 7
  • AD leads to milia and scarring
  • AR - Severe blisters, scarring, contractoins
25
Q

Acquired

A
  • Ab to lamina lucida

- Dermal split blisters

Dermatology Mayo (26 decks)

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