Ch 21 Skin and Systemic Disease

Question 1

Malignancy

Answer 1

• Acanthosis Nigricans
• Pruritus: Hodgkins/Lymphoma
• Dermatomysoitis
• Necrolytic Migratory: GNG oma
• Lanugo, eryhtema, gyratum, icthyosis
• When in doubt think of leukemia/lymphoma

Question 2

DM

Answer 2

• Necrobiosis Lipodica: Discoloration and spreading inflammation, generally follows trauma and keeps growing. Steroids are ineffective. Occurs commonly on the shins
• GA, Cheriopathy(Thickening of skin)

Question 3

Sarcoid

Answer 3

• EN, Granulomas, Lupus Pernio

- granulomas often have a dusky appearance

Question 4

Liver

Answer 4

• Hep C can cause Lichen Planus

- Hep B can cause PAN

Question 5

Vit A

Answer 5

-Follicular hyperkeratosis, xerosis

Question 6

B1

Answer 6

Beri Beri

Question 7

B2 Riboflavin

Answer 7

Angular stomatitis, chelitis, smooth tongue, seb derm

Question 8

Niacin

Answer 8

DDD, Pellegra

Question 9

C

Answer 9

Scurvy

Question 10

Congenital Erythropoetic Porphyria

Answer 10

• Mutilation and sever photosensitivity

- Uroporphryin III

Question 11

Erythropoetic

Answer 11

Ferrocheletase

• Less severe, blisters and liver diesease
• Can give beta carotene

Question 12

CPT

Answer 12

Most commonly acquired by liver disease but also congenital

• Uroporphyrinogen Decarboxylase
• Pink urine, blisters/milia

Question 13

AIP

Answer 13

Prophobilinogen

-Abdoinal pain and psychiatric

Question 14

Pseudo

Answer 14

Drugs (NSAIDs, Furosemide)

Question 15

Amyloidosis

Answer 15

• Pinch Purpura

- Waxy appearance like scleroderma

Question 16

Xanthomas

Answer 16

Described by anatomic location

-Be sure to check blood lipid levels

Question 17

Fabrys

Answer 17

Telangectatic papules around the umbilicus and renal failure

-Alpha galactosideas

Question 18

Pydorema Gangrenosum

Answer 18

• Serpiginous outline with indermined blue edge

- With RA, IBD, Hematologic Malignancy