Ch 2 Function of Skin Flashcards
Layers
Basal to spinous
Granular to horny
Basal and spinous
Cells aquire tonofilaments and use keratin 5,14 (EB Simplex)
Granular and Horny
Acquire Keratin 1,10
Also desmogleins/colins
Form lamellar bodies
Form keratohyalin granules using filaggrin(AD icthyosis) and steroid sulphatase (XLR Icthyosis)
IL-1
Keratinocytes, activate lymphocytes and langerhans cells
IL-3
Colony stimulating factor
IL-6
B cell differentiatio
IL-8
Neutrohil chemotactic
IL-10
Inhibit TH1
IL-12
Induce TH1
TGF
-Inhibit inflammation and increase fibroblast function
TNF
TH1, Apoptosis, Cell mediated, inflammatory response
IFNa
Antiviral
IFNy
Type 4, decrease keratinocyte proliferation
Desmoglein 1, 3
located in epidermis (3 is PV)
-1 is SSS
(enriched in outer layers)
Hemidesmososmes
Integrins and BP antigens
Lamina Lucida
-Laminin 1,5
Anchoring Filaments
-Col VII
Dermal Cells
Fibs: ECM, Scar Monocyte: Cytokines, TH1 Lymphocyte Langerhans (also epidermal) Mast-Histamin, eos and neut chemotactic Merkel-fine touch
Col 1
Bone, tendon
Col 2
Cartillage
Col 3
Blood Vessels
Col 4
Lamina Densa
Col 5
Placenta
VII
Anchornig fibril (Dystrophic EB)
Activated Keratinocytes
IL-1, TGF, TNF Induce inflammation and healing
Langerhans Marker
CD1a, MHC2, S-100 (also present on melanocytes)
T Lymphs
Th1-IL-12 (2, TNF, IFN)
Th2-IL-4 (10, 4,5)
Th17-IL-23 (22, 17)
Interactions with Ag Cells
LFA and CD
LFA and Vcam
CD28, B7
Cadherins
Interact with other cadherins
Desmogleins.colins
IG
CAMS interact with LFA
Integrins
LFA ineracti with Cams
Selectins
Endothelium
Interact with CHO
