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Dermatology Mayo > Ch 2 Function of Skin > Flashcards

Ch 2 Function of Skin Flashcards

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Dermatology Board Prep flashcards
1
Q

Layers

A

Basal to spinous

Granular to horny

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2
Q

Basal and spinous

A

Cells aquire tonofilaments and use keratin 5,14 (EB Simplex)

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3
Q

Granular and Horny

A

Acquire Keratin 1,10
Also desmogleins/colins
Form lamellar bodies
Form keratohyalin granules using filaggrin(AD icthyosis) and steroid sulphatase (XLR Icthyosis)

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4
Q

IL-1

A

Keratinocytes, activate lymphocytes and langerhans cells

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5
Q

IL-3

A

Colony stimulating factor

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6
Q

IL-6

A

B cell differentiatio

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7
Q

IL-8

A

Neutrohil chemotactic

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8
Q

IL-10

A

Inhibit TH1

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9
Q

IL-12

A

Induce TH1

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10
Q

TGF

A

-Inhibit inflammation and increase fibroblast function

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11
Q

TNF

A

TH1, Apoptosis, Cell mediated, inflammatory response

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12
Q

IFNa

A

Antiviral

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13
Q

IFNy

A

Type 4, decrease keratinocyte proliferation

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14
Q

Desmoglein 1, 3

A

located in epidermis (3 is PV)
-1 is SSS
(enriched in outer layers)

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15
Q

Hemidesmososmes

A

Integrins and BP antigens

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16
Q

Lamina Lucida

A

-Laminin 1,5

17
Q

Anchoring Filaments

A

-Col VII

18
Q

Dermal Cells

A 
Fibs: ECM, Scar
Monocyte: Cytokines, TH1
Lymphocyte
Langerhans (also epidermal)
Mast-Histamin, eos and neut chemotactic
Merkel-fine touch
19
Q

Col 1

A

Bone, tendon

20
Q

Col 2

A

Cartillage

21
Q

Col 3

A

Blood Vessels

22
Q

Col 4

A

Lamina Densa

23
Q

Col 5

A

Placenta

24
Q

VII

A

Anchornig fibril (Dystrophic EB)

25
Q

Activated Keratinocytes

A

IL-1, TGF, TNF Induce inflammation and healing

26
Q

Langerhans Marker

A

CD1a, MHC2, S-100 (also present on melanocytes)

27
Q

T Lymphs

A

Th1-IL-12 (2, TNF, IFN)
Th2-IL-4 (10, 4,5)
Th17-IL-23 (22, 17)

28
Q

Interactions with Ag Cells

A

LFA and CD
LFA and Vcam
CD28, B7

29
Q

Cadherins

A

Interact with other cadherins

Desmogleins.colins

30
Q

IG

A

CAMS interact with LFA

31
Q

Integrins

A

LFA ineracti with Cams

32
Q

Selectins

A

Endothelium

Interact with CHO

Dermatology Mayo (26 decks)

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