Ch 19 Disorders of Pigmentation Flashcards
Hypopigmentation Tyrosine
-Albinism, Pitaryasis Versicolor, PKU, Endocrine
Hypopigmentation Melanocytes
-Vitiligo, Piebaldism, Rubber
Hyperpigment Melanocytes
-Lentigo, Nevi, Melanoma, Cafe au lait
Hyperpigment Melanin
-Ephiledes, Race,
Albinism
- Tyrosine + and - determined by hairpull
- + can recover some later inlife, negative never does
Piebaldism
- KIT impairs melanocyte migration, white forelock
- CH and HP are variants
Vitiligo
-Destruction of melanocytes generalized is associated with autoimmunity and segmental is not
Ephiledes
-Freckle is increase in melanin with same number of melanocytes
Lentigo
Increased melanocytes
Nevi
Increased melanocytes along with melanoma
LentigoSyndromes
- Puetz Jegher: Polyps in GI tract
- LEOPARD: heart and deafness
Drugs
Busulfan, bleomycin, minocycline
Dermal
Inflamation and mongolian stpots and drugs.