Ch 25 Drug Eruptions Flashcards
1
Q
Causes of Drug Eruptions
A
- Pharmacology
- Allergy (1,2,3,4)
- Cummulative
- Altered skin ecology
- Overdose
- Idiosyncratic
- Exacerbation
2
Q
Examples of non allegic
A
- MTX causing mouth ulcer
- Hydralazine, Minocycline causing lupus
- Dapsone/Rifampin causing reversal reactions in leoprosy
- Candidal Vaginitis with Abx
3
Q
Cell types and reactions
A
CD4 tends to be morlbilliform
CD8 tends to be TEN and necrotisc
4
Q
6 Questions to ask
A
- Can this be explained by a simple dermtosis
- Does rash suggest a drug eruption
- Past history of drug eruprtions
- Current drugs takin
- Recent changes in drugs
- Pattern of eruption with known drugs
5
Q
Abx
A
- Mostly are toxic erythema but can cause a wide range
- Minocycline causes hyperpigmentation and can cause a lupus like syndrome
6
Q
Penicillamine
A
-Most famous for pemphigus like with blood bullae
7
Q
Gold
A
-Can cause anything
8
Q
Anticonvulsants
A
-Most famous for SJS/TEN
9
Q
Toxic Erythema
A
-Most common urticarial/morbilliform rash
10
Q
Vasculitis
A
EN, PAN, etc
11
Q
EM
A
Sulfa and anticonvulsants
12
Q
Fixed Drug
A
- Purple papules that occur in the same place every time
- Penis
- Psychotropic, Abx, antifungals
13
Q
Acneiform
A
-Li, Convulsants, TB
14
Q
DRESS
A
Eosinophilia and internal organ involvment, significant rash and fever
-Fever with rash and drugs is always a bad sign
15
Q
Photosensitivity
A
- Sulphur containing drugs
- thiazides, tetracyclines,
