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Derm1 > Ch. 7 - Interface dermatitis > Flashcards

Ch. 7 - Interface dermatitis Flashcards

1
Q

Lichenoid interface dermatitis

A

Destruction of basal layer with civatte bodies and sawtooth rete pattern. Hyperkeratosis and hypergranulosis are typically present.

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2
Q

Causes of lichenoid interface dermatitis

A

Lichen planus

Benign lichenoid keratosis

Lichenoid drug eruption

Lichenoid GVHD

Hypertrophic lupus erythematosis

Lichenoid regression of melanocytic lesion

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3
Q

Late-phase (burnt out) lichenoid dermatitis

A

Effacement of the rete with civatte bodies and melanin pigment incontinence (melanoderma)

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4
Q

Lichen planus

A

Lichenoid interface dermatitis with sawtooth rete ridge s and no parakeratosis or eosinophils

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5
Q

Lichenoid drug eruption

A

Lichenoid interface dermatitis with eosinophils and parakeratosis

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6
Q

Benign lichenoid keratosis

(early stage?)

A

Lichenoid interface dermatitis with parakeratosis and solar lentigo at the margin

In early stage, looks vacuolar with lymphocytes in nearly every vacuole.

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7
Q

Hypertrophic lupus erythematosus

A

Lichenoid interface dermatitis with rare parakeratosis and eosinophils, with granular DIF at the basement membrane, also CD123+ dendritic cells adjacent to the epithelium.

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8
Q

Lichenoid regression of lentigo maligna

A

Lichenoid interface dermatitis in an area of heavily sun-damaged skin, sometimes with parakeratosis.

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9
Q

Porokeratosis

A

Cornoid lamellae with lichenoid or psoriasiform zones between.

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10
Q

Vacuolar interface dermatitis

A

Intact but vacuolated basal layer with a rounded rete pattern. Look for lymphocytes in the vacuoles to narrow the differential.

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11
Q

Mycosis fungoides

A

Vacuolar interface dermatitis with atypical CD7- lymphocytes in nearly every vacuole. Little accompanying spongiosis. Epidermal Pautrier microabscesses.

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12
Q

Pityriasis lichenoides et varioliformis acuta (PLEVA), Pityriasis lichenoides chronica

A

Vacuolar interface dermatitis with a lymphocyte in nearly every vacuole. Keratinocyte necrosis and transepidermal elimination of erythrocytes.

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13
Q

Lupus erythematosus (non-lichenoid)

A

Vacuolar interface dermatitis with compact and follicular hyperkeratosis, perivascular/periadnexal lymphocytes. Melanoderma. DIF is negative in early lesions.

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14
Q

Dermatomyositis

A

Similar to lupus erythematosus (vacuolar interface dermatitis with lymphocytes and parakeratosis) but with epidermal atrophy.

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15
Q

Lichen striatus

A

Blaschkoid interface dermatitis, similar to lupus (perivascular and eccrine lymphocytes), but without dermal mucin.

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16
Q

Polymorphous light eruption

A

Can be papulovesicular (spongiotic) or plaque variant (papillary dermal edema and dense perivascular lymphoid infiltrate)

17
Q

Syphilis

A

Vacuolar interface dermatitis with slender acanthosis. Epidermis can be atrophic with neutrophils in the SC. Endothelial swelling obliterates small vessels.

18
Q

Erythema multiforme

A

Vacuolar interface dermatitis with necrotic keratinocytes or confluent epidermal necrosis out of proportion to lymphocytes. Later, bulla and re-epithelialization occur.

19
Q

Toxic epidermal necrolysis

A

Looks identical to erythema multiforme (vacuolar interface dermatitis with epidermal necrosis out of proportion to lymphocytes).

20
Q

Fixed drug eruption

A

Vacuolar interface dermatitis with polymorphous infiltrate (with eosinophils), papillary dermal fibrosis, and perivascular melanin incontinence.

21
Q
A

Lichenoid interface dermatitis

22
Q
A

Lichen planus

23
Q
A

Lichenoid drug eruption

24
Q
A

Benign lichenoid keratosis

25
Q
A

Hypertrophic lupus erythematosus

26
Q
A

Lichenoid regression of lentigo maligna

27
Q
A

Porokeratosis

28
Q
A

Mycosis fungoides

29
Q
A

Pityriasis lichenoides et varioliformis acuta

30
Q
A

Pityriasis lichenoides chronica

31
Q
A

Acute lupus erythematosus

32
Q
A

Chronic lupus erythematosus

33
Q
A

Polymorphous light eruption

34
Q
A

Lichen striatus

35
Q
A

Dermatomyositis

36
Q
37
Q
A

Erythema multiforme

38
Q
A

Fixed drug eruption

39
Q
A

Graft versus host disease

Derm1 (30 decks)

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