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Derm1 > Ch. 20 - Fibrous tumors > Flashcards

Ch. 20 - Fibrous tumors Flashcards

1
Q

Dermatofibroma

A

Interstitial spindle cells with collagen trapping and overlying acanthosis. Ringed lipidized siderophages. Factor XIIIa+, CD34-.

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2
Q

Aneurysmal dermatofibroma (sclerosing hemangioma)

A

A type of dermatofibroma with aneurysmal dilatation of vessels.

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3
Q

Fibrous histiocytoma

A

A type of dermatofibroma with large histiocytoid vesicular nuclei with prominent nucleoli.

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4
Q

Dermatofibroma with monster cells

A

A type of dermatofibroma with very large cells with vesicular nuclei and prominent nucleoli. Benign!

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5
Q

Adult myofibroma

A

Blue myxoid nodules with myofibroblasts and peripheral fibrovascular proliferation.

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6
Q

Dermatomyofibroma

A

Plaque-like tumor with horizontally-aligned spindle cells which “respect” adnexal structures.

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7
Q

Fibromatosis

A

Corkscrew-shaped myofibroblasts and collagen. Locally infiltrate but not metastatic.

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8
Q

Infantile myofibromatosis

A

Fibromatosis in children which tends to spontaneously regress (become less cellular and more fibrous). Visceral inolvement can be fatal.

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9
Q

Juvenile hyaline fibromatosis

(cause?)

A

Nodular hyaline fibrosis in the dermis. Affects face, hands, joints, gingiva.

AutRec CMG2/ANTXR2 mutations

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10
Q

Scar, hypertrophic scar, keloid

A

Scar: Horizontally-aligned fibroblasts and vertically-aligned blood vessels. No elastic tissue.

Hypertrophic: Whorled proliferation

Keloid: Central bundles of amorphous “bubble-gum” collagen.

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11
Q

Fibrous hamartoma of infancy

A

Disordered myxoid and mature fibrous and fatty areas with compartmentalized appearance.

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12
Q

Infantile digital fibroma (inclusion body fibroma)

A

Criss-cross fascicles of spindle cells with red inclusion bodies (actin?).

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13
Q

Giant cell tumor of the tendon sheath

A

Osteoclast-like giant cells (randomly distributed nuclei) with plump fibroblasts and collagen+hemosiderin.

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14
Q

Fibroma of tendon sheath

A

Essentially, giant cell tumor of tendon sheath without the giant cells. Bland, plump fibroblasts.

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15
Q

Elastofibroma dorsi

A

Large fibrous tumor with deposits of beaded elastic fibers.

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16
Q

Sclerotic fibroma

(association?)

A

“Starry sky” whorls of hypocellular collagen.

Associated with Cowden’s syndrome

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17
Q

Pleomorphic fibroma

A

Scattered large hyperchromatic stellate nuclei. No mitoses! CD34+.

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18
Q

Sclerosing perineurioma

A

Whorled, nodular, or storiform concentric appearance. EMA+.

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19
Q

Angiofibromas

A

Concentric perivascular fibrosis with stellate, factor XIIIa+ stromal cells.

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20
Q

Fibrous papule of the face (benign fibrous papule, solitary angiofibroma)

A

Common type of angiofibroma with large pyramid-shaped melanocytes at the dermal-epidermal junction.

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21
Q

Acquired digital fibrokeratoma

A

An acral angiofibroma with hyperkeratosis, acanthosis, and hypergranulosis.

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22
Q

Nodular fasciitis

A

“Tissue culture” loose myxoid pattern of fibroblasts with erythrocytes and inflammatory cells.

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23
Q

Cranial fasciitis, proliferative fasciitis

A

Cranial: Variant of nodular fasciitis that occurs on head of a child

Proliferative: Variant of nodular fasciitis with ganglion-like giant cells and peripheral collagen trapping

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24
Q

Calcifying aponeurotic fibroma

A

Plump, epithelioid fibroblasts palisading around chondroid foci sometimes with calcification and/or osteoclast-like cells.

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25
Q

Desmoid tumor (aggressive fibromatosis)

A

Bland myofibroblastic proliferation with tendency for deep infiltration and recurrence (borderline). Beta-catenin+.

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26
Q

Plexiform fibrohistiocytic tumor

A

Biphasic tumor with plexiform fascicles of fusiform/spindle cells and nodules of histiocytic/osteoclast giant cells.

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27
Q

Dermatofibrosarcoma protuberans (DFSP)

IHC? Molecular?

A

Malignant storiform lesion that infiltrates fat and effaces epidermal rete.

CD34+, Factor XIIIa-. t(17;22) COL1A1-PDGFB

28
Q

Bednar tumor, Giant cell fibroblastoma

A

Bednar: Pigmented DFSP

Giant cell fibroblastoma: A juvenile variant of DFSP with multinucleated giant cells lining vascular-like spaces.

29
Q

Fibrosarcoma

A

Densely hypercellular herringbone lesion with large and hyperchromatic nuclei.

30
Q

Atypical fibroxanthoma (AFX)

A

An atypical pleomorphic/spindle cell lesion. Diagnosis of exclusion, CD10+, S100A6+, Procollagen+.

31
Q

Pleomorphic undifferentiated sarcoma

A

A heterogeneous group of soft tissue sarcomas. Replaced the former malignant fibrous histiocytoma.

32
Q

Epithelioid sarcoma

A

Biphasic sarcoma resembling a palisading granuloma. Central necrosis, stains for both keratin and vimentin.

33
Q
A

Dermatofibroma

34
Q
A

Aneurysmal dermatofibroma

35
Q
A

Fibrous histiocytoma

36
Q
A

Dermatofibroma with monster cells

37
Q
A

Adult myofibroma

38
Q
A

Dermatomyofibroma

39
Q
A

Fibromatosis (dupuytren’s contracture)

40
Q
A

Juvenile hyaline fibromatosis

41
Q
A

Scar

42
Q
A

Hypertrophic scar

43
Q
A

Keloid

44
Q
A

Fibrous hamartoma of infancy

45
Q
A

Infantile digital fibroma

46
Q
A

Giant cell tumor of tendon sheath

47
Q
A

Fibroma of tendon sheath

48
Q
A

Elastofibroma dorsi

49
Q
A

Sclerotic fibroma

50
Q
A

Pleomorphic fibroma

51
Q
A

Sclerosing perineurioma

52
Q
A

Angiofibroma

53
Q
A

Fibrous papule of the face

54
Q
A

Acquired digital fibrokeratoma

55
Q
A

Nodular fasciitis

56
Q
A

Proliferative fasciitis

57
Q
A

Calcifying aponeurotic fibroma

58
Q
A

Desmoid tumor

59
Q
A

Plexiform fibrohistiocytic tumor

60
Q
A

Dermatofibrosarcoma protuberans

61
Q
A

Bednar tumor

62
Q
A

Giant cell fibroblastoma

63
Q
A

Fibrosarcoma

64
Q
A

Atypical fibroxanthoma

65
Q
A

Epithelioid sarcoma

Derm1 (30 decks)

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