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Derm1 > Ch. 13 - Alterations in collagen and elastin > Flashcards

Ch. 13 - Alterations in collagen and elastin Flashcards

1
Q

Lichen sclerosus et atrophicus

A

Compact stratum corneum, papillary dermal pallor, and blue band of lymphoid inflammation

(equivalent to BXO on glans penis)

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2
Q

Chronic radiation dermatitis

A

Papillary dermal pallor without lymphoid band or lymphoid band. Radiation elastosis and large stellate fibroblasts. Ectatic vessels.

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3
Q

Morphea/scleroderma

A

Thick, closely packed, hyalinized collagen with “trapped eccrine glands” (loss of adventitial fat). Sparse inflammation.

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4
Q

Sclerodermoid GVHD

A

Thickened and sclerotic dermis with destroyed adnexal structures and minimal basal vacuolization.

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5
Q

Eosinophilic fasciitis (Shulman’s syndrome)

A

Thick eosinophilic fascia due to fibrosis and hyalinization of collagen. Variable eosinophilic infiltrate.

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6
Q

Elastosis perforans serpiginosa

A

Tortuous channel through an acanthotic epidermis with large bulky red elastic fibers.

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7
Q

What is in the differential for a thickened sclerotic stroma?

A

Morphea/scleroderma

Chronic GVHD

Chronic radiodermatitis

Scar

Connective tissue nevi

Scleroderma

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8
Q

What diseases are associated with elastosis perforans serpiginosa?

A

Rothmund-Thompson syndrome

Acrogeria

Penicillamine

Marfan’s syndrome

Osteogenesis imperfecta

Pseudoxanthoma elasticum

Ehlers-Danlos syndrome

Down syndrome

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9
Q

Reactive perforating collagenosis

A

Broad vetical channel of degenerated basophilic collagen bundles (use Masson trichrome).

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10
Q

Hypertrophic scar

A

Fibroblasts with “east-west” orientation, blood vessels with “north-south” orientation. Nodules or whorls of thickened collagen and fibroblasts.

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11
Q

Keloid

A

Fibroblasts with “east-west” orientation, blood vessels with “north-south” orientation. Broad, hyalinized, eosinophilic “bubble gum” collagen fibers.

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12
Q

Acne keloidaris nuchae

A

Hypertrophic scar with suppurative folliculitis with hair shafts free in the dermis and plasma cell infiltrate.

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13
Q

Favre-Racouchot syndrome (nodular elastosis with cysts and comedones)

A

Dilated, keratin-filled follicles, small cysts, and solar elastosis.

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14
Q

Chondrodermatitis nodularis helicis

A

Ulcer/erosion with adjacent acanthosis overlying a zone of fibrin (flanked by granulation tissue).

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15
Q

Acrodermatitis chronic atrophicans

(cause?)

A

Early: “Polka dot” lymphoplasmacytic infiltrate

Late: Epidermal/dermal atrophy with attenuated wispy collagen.

(Lyme disease, tertiary)

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16
Q

Ochronosis (alkaptonuria)

A

Glassy yellow-brown banana-shaped deposits in the dermis

17
Q

Colloid milium

A

Pale pink, fissured deposits of amorphous material.

18
Q

Anetoderma

A

Normal H&E but sprase to absent elastic fibers on elastin stains.

19
Q

Atrophoderma

A

Subtly reduced dermal thickness.

20
Q

Connective tissue nevus

A

Collagenoma (haphazard broad collagen bundles) vs Elastoma (broad, branching elastic fibers).

21
Q

Aplasia cutis congenita

A

Absent or thin epidermis with absent or rudimentary adnexae.

22
Q
A

Lichen sclerosus et atrophicus

23
Q
A

Chronic radiation dermatitis

24
Q
A

Morphea / Scleroderma

25
Q
A

Sclerodermoid GVHD

26
Q
A

Eosinophilic fasciitis

27
Q
A

Elastosis perforans serpiginosa

28
Q
A

Reactive perforating collagenosis

29
Q
A

Hypertrophic scar

30
Q
A

Keloid scar

31
Q
A

Acne keloidalis nuchae

32
Q
A

Favre-rocouchot syndrome

33
Q
A

Chondrodermatitis nodularis helicis

34
Q
A

Acrodermatitis chronica atrophicans

35
Q
A

Ochronosis

36
Q
A

Colloid milium

37
Q
A

Anetoderma

38
Q
A

Collagenoma

Derm1 (30 decks)

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