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Derm1 > Ch. 5 - Sweat gland neoplasms > Flashcards

Ch. 5 - Sweat gland neoplasms Flashcards

1
Q

What is “focal decapitation secretion”?

A

A hallmark of apocrine differentiation in sweat gland tumors

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2
Q

What do “red” and “blue” sweat gland tumors differentiate towards?

A

Red - Sweat duct

Blue - Secretory component

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3
Q

Cylindroma (turban tumor)

A

Islands of blue cells in a jigsaw-puzzle pattern outlined by a deeply eosinophilic basement membrane.

Inherited and multiple on the scalp.

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4
Q

Spiradenoma

A

Very large round islands of blue cells peppered with lymphocytes (tender). Can have eosinophilic hyaline droplets.

Sporadic and solitary.

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5
Q

Recite the mnemonic for tender skin tumors.

A

BANGLE:

Blue rubber bleb nevus

Angiolipoma

Neuroma (neurilemmoma)

Glomus tumor

Leiomyoma

Eccrine spiradenoma

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6
Q

Spiradenocarcinoma

A

Atypia, mitoses, and necrosis arising in long-standing spiradenomas.

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7
Q

Syringocystadenoma papilliferum (SPAP)

A

Papillary lesion open to surface with decapitation secretion and plasma cells.

Can occur within nevus sebaceus.

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8
Q

Hidradenoma papilliferum (HPAP)

A

Blue papillary dermal nodule with branching cystic spaces and decapitation secretion.

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9
Q

Papillary digital carcinoma

(+epidemiology)

A

Blue tumor with papillary fronds and cystic changes. Atypia with mitoses and necrosis.

Usually involves the hands of young patients

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10
Q

Mucinous carcinoma

A

Islands of blue cells in a sea of mucin.

Can be primary in the skin or metastatic from breast or GI tract (looks identical).

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11
Q

Syringoma

(+epidemiology)

A

Paisley-pattern of ducts with ample pink cytoplasm in a dense sclerotic stroma.

Usually in asian women and children with Down’s syndrome.

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12
Q

Clear cell syringoma

A

Tadpole-shaped ducts with clear glycogenated cells in a dense sclerotic stroma.

Associated with diabetes mellitus.

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13
Q

Microcystic adnexal carcinoma

A

Deeply invasive biphasic pattern (sweat duct-like and pilar) with tadpole-shaped ducts and basaloid nests with pilar differentiation. Dense sclerotic stroma and lymphoid aggregates.

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14
Q

Sclerosing weat duct carcinoma

A

Monophasic variant of MAC with only the tadpole component in a sclerotic stroma with lymphoid aggregates.

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15
Q

Hidrocystoma

A

Simple cyst lined with cuboidal or columnar cells with decapitation secretion.

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16
Q

Mixed tumor (chondroid syringoma)

A

Sweat ducts with ample pink cytoplasm embedded in a mesenchymal stroma often with cartilaginous or bone formation.

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17
Q

Small tubular type mixed tumor

A

Small tubule sweat ucts with ample pink cytoplasm embedded in a mesenchymal stroma often with cartilaginous differentiation.

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18
Q

Branching alveolar type

A

Sweat ducts with a long, branching and alveolar pattern in a mesenchymal stroma often with cartilaginous differentiation.

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19
Q

Malignant mixed tumor (malignant choroid syringoma)

A

Sweat ducts with atypia, mitoses, and necrosis embedded in a mesenchymal stroma often with cartilaginous differentiation.

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20
Q

Acrospiroma

A

Cuboidal pink cells with a tendency towards clear cell degeneration with cuticle lined ducts.

(a large family of sweat gland tumors)

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21
Q

Poroma

A

Cuboidal cells with ample pink cytoplasm with cuticle-lined ducts. Connects to the epidermis and commonly found on the foot.

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22
Q

Hidroacanthoma simplex

A

Intraepidermal nests of cuboidal cells with ample pink cytoplasm resembling clonal seborrheic keratosis, but containing ducts.

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23
Q

Dermal duct tumor

A

Small dermal nodules of cuboidal cells with ample pink cytoplasm and cuticle-lined ducts.

24
Q

Nodular hidradenoma

A

Large dermal nodule of cuboidal pink cells and cuticle-lined ducts with bright red zones of basement membrane zone reduplication.

25
Q

Clear cell hidradenoma

A

Large dermal nodule with pink cuboidal cells with clear cell and cystic degeneration and red ones of BMZ reduplication around vessels.

26
Q

Malignant acrospiroma (porocarcinoma)

A

Invasive pink cuboidal cells with atypia, mitoses, and necrosis, with cuticle-lined ducts.

27
Q

Syringofibroadenoma of Mascaro

A

A usually reactive lesion with parallel or anastomosing ducts in a fibromyxoid stroma.

Associated with hidrotic ectodermal dysplasia and Schopf syndrome.

28
Q

Papillary “eccrine” adenoma (tubular apocrine adenoma)

A

Dilated duct-like spaces with blue papillary projections. Has differentiation towards both secretory segmenet and duct.

29
Q

Adenoid cystic carcinoma

A

Cribriform and tubular glands with variable atypia and mitoses.

30
Q

Eccrine angiomatous hamartoma

A

Collection of mature sweat glands and vessels presenting in children.

31
Q
A

Cylindroma

32
Q
A

Spiradenoma

33
Q
A

Spiradenocarcinoma

34
Q
A

Syringocystadenoma papilliferum

35
Q
A

Hidradenoma papilliferum

36
Q
A

Papillary digital carcinoma

37
Q
A

Mucinous carcinoma

38
Q
A

Syringoma

39
Q
A

Clear cell syringoma

40
Q
A

Microcystic adnexal carcinoma

41
Q
A

Sclerosing sweat duct carcinoma

42
Q
A

Hidrocystoma

43
Q
A

Mixed tumor, small tubular type

44
Q
A

Mixed tumor, branching alveolar type

45
Q
A

Malignant mixed tumor

46
Q
A

Hybrid acrospiroma

47
Q
A

Poroma

48
Q
A

Hidroacanthoma simplex

49
Q
A

Dermal duct tumor

50
Q
A

Nodular hidradenoma

51
Q
A

Clear cell hidradenoma

52
Q
A

Malignant acrospiroma

53
Q
A

Syringofibroadenoma of Mascaro, neoplastic type

54
Q
A

Papillary “eccrine” adenoma

55
Q
A

Adenoid cystic carcinoma

56
Q
A

Eccrine angiomatous hamartoma

Derm1 (30 decks)

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