Ch:6 Myoglobin and Hemoglobin Flashcards
Myoglobin is a globular protein found in _____ and ____ muscle.
skeletal and cardiac muscle
Which has a higher affinity for O2? hemoglobin or myoglobin?
Myoglobin has a higher affinity for O2
Why do whales and seals have high amounts of myoglobin?
So they can hold their breath under water longer
(Myoglobin stores O2)
“THIS IS A FAVORITE DAT-TYPE QUESTION”
(T/F)
Globular proteins are hydrophobic and water insoluble.
FALSE
Globular proteins are hydrophilic and water soluble
When a heart or skeletal muscle is injured, large amounts of _______ is released into the blood.
Myoglobin
What has a darker color, myoglobin or hemoglobin?
Myoglobin
______ is found exclusively in RBCs where it’s job is to transport O2 from the lungs to the tissue capillaries.
Hemoglobin
How many heme do myoglobin and hemoglobin contain?
Myoglobin = 1 heme
Hemoglobin = 4 heme
Hb is a ___1___ and shows what is called ___2___ binding, meaning the more O2 it binds the easier it can bind with even more O2.
- Tetramer
2. Cooperative
Which of the following is an allosteric protein?
A. Myoglobin
B. Hemoglobin
B. Hemoglobin
At a LOW blood pH, the hemoglobin curve will “shift to the right”.
What does this mean?
O2 is dumped from hemoglobin into the blood to bring the blood pH back up
____1___ causes O2 to be dumped off and our Hb curve will shift to the __2__.
- BPG (2,3-DPG)
2. Right
If you ever see this expression “shift to the right” and the DAT loves it… It simply means that Hb is ____________.
Dumping off O2 to the tissues in need
What has a higher affinity for O2 and why?
A. Fetal Hemoglobin
B. Adult Hemoglobin
A. Fetal hemoglobin because of 2 gamma sheets and because fetal Hb binds BPG less tight
In Sickle Cell anemia, a _____ is converted to _____. The mutation was on a hemoglobin __-chain.
Glutamic acid —> Valine
The mutation was on a hemoglobin BETA-chain (A FAVORITE DAT QUESTION)
