Ch 51 Flashcards
Stage 1 of Hemostasis is formation of platelet plug which consists of what
Platelet aggregation. The plug is unstable without fibrin reinforcement
Hemostasis is what
Process by which blood is stopped
Stage 2 of Hemostasis is coagulation and involves what two systems *necessary factors for clotting are present within vascular system *thromboplastin comes from outside vascular system
Instrinsic and extrinsic
Coagulation factors need what vitamin for synthesis
k
What inactivates clotting factors
Antithrombin III
What does plasmin do
It’s an enzyme that digests fibrin mesh work (clot)
What are 4 drugs that convert plasminogen to plasmin
Streptokinase
Urokinase
Alteplase
Antistreplase
What is thrombosis
Blood clot formed within a blood vessel or within the heart
Arterial thrombosis begins with adhesion of platelets to the arterial wall and venous thrombosis is
A clot that develops at site of slow blood flow
What are 3 drug classes that treat thromboembolic disorders
anti platelet drugs
Anti coagulant drugs
Thrombolytic drugs
What are three major groups of anti platelet drugs
Aspirin
Ticlopidine
Tirofiban
Aspirin inhibits cyclooxygenase (enzyme) that’s necessary for platelets to produce TXA2 and TXA2 induces what two things
Platelet aggregation
Vasoconstriction
Heparin is a rapid acting anticoagulant and helps anti thrombin III inactivate thrombin and is used for what 3 things
Pulmonary edema
Stroke
Vein thrombosis
Heparin has what 3 adverse effects
Hemorrhage
Thrombocytopenia
Hypersensitivity reactions
Warfarin (Coumadin) suppresses coagulation by acting as an antagonist of what
Vitamin k
