Ch 44 Flashcards
Calcium channels are always coupled with what other receptors?
Beta 1 adrenergic receptors
Calcium channels help regulate functions of what 3 areas
Myocardium
SA node
AV node
Calcium channel blockers / calcium antagonist prevent calcium ions from doing what
Entering cells therefor preventing contraction
CCBs and beta blockers have the same action on heart and that’s what
Reduce force of contraction and slow heart rate
What are three classes of CCBs
Nifedipine
Verapamil
Diltiazem
Nifedipine (adalat) - CCB blocks calcium in blood vessels (arterioles only) causing vasodilation. The three major indications are what
Angina pectoris
Hypertension
Migraine headaches
Verapamil (calan) - CCB blocks calcium in blood vessels and heart. Three major indications are what
Angina pectoris
Essential hypertension
Cardiac dysthymias
What are 7 adverse effects of verapramil (CCB)
Constipation Dizziness Facial flushing Headache Edema of ankles Gingival hyperplasia (overgrowth of gum tissue) Heart block
CCBs should be used with GREAT CAUTION because of increased risk of mortality in patients with what 3 disorders
Myocardial infarction
Unstable angina
Hypertension