Ch 30 Fundamental Principles of Radiobiology Flashcards
What are the different names for Stem Cells?
- Immature Cells
- Precursor
- Undifferentiated Cells
What type of cells are sensitive to Radiation?
Immature cells
What does proliferation mean?
The splitting/ dividing of cells
What happens to cells the more mature they are?
They become more resistant to radiation
What is the law needed to understand the biologic effects of radiation?
The Law of Bergonie and Tribondeau
What are the Laws of Bergonie and Tribondeu?
- Stem cells are radiosensitive, the more mature a cell, the more resistant to radiation
- The younger the tissue, the more radiosensitive
- When metabolic activity is high, radio sensitivity is high
- As proliferation increases, so does radio sensitivity
What is the radiosensitvity of cells proportional to?
Their reproductive activity
The radio sensitivity is inversely proportional to:
Their degree of differentiation
When does the most pronounced radiation effects in cells occur?
When they have the least maturity and specialization or differentiation
What law mainly has application in Radiation Therapy?
The law of Bergoine and Tribondeau
What type of cell is more sensitive to radiation, immature or mature cells?
Immature cells
What does LET stand for?
Linear Energy Transfer
What does RBE stand for?
Relative Biologic Effectiveness
What does OER stand for?
Oxygen Enhancement Ratio
What are the (3) attributes that determine the extent to which radiation energy is transferred into biologic tissue?
LET
RBE
OER
What is the rate radiation energy is transferred into soft tissue in diagnostic x-rays?
3 keV
What is an important factor in assessing potential tissue and organ damage from exposure to ionizing radiation?
LET
What two categories, can LET be divided into?
High and Low
What attribute is a method of expressing radiation quality?
LET
What are examples of Low- LET radiation?
External Electromagnetic Radiations
- X-rays - Gamma rays
Does low LET relinquish their energy quickly or over a sustained amount of time?
Over time
How does low LET cause damage?
Primarily through indirect action; involves free radicals