ch 18 pt 2

Question 1

proliferative lesion due to increased estrogen, pt’l from obesity or taken exogenously

Answer 1

endometrial hyperplasia

Question 2

______ carcinoma is the MC female genital tract CA, seen in pt 55-65 yo, and is MC of ______ type (80%)

• infiltrative or exophytic
• increased estrogen/obesity

Answer 2

endometrial

endometrioid

Question 3

endometrial polyps have pt’l to be pre-cancerous and can occur at any age, but are MC around the time of:

Answer 3

menopause

Question 4

smooth muscle tumors of the myometrium can be the BENIGN _____ “fibroids” or the MALIG ______

Answer 4

leiomyoma

leiomyosarcoma

Question 5

leiomyoma are mc during ____ age (30-50%) while leiomyoSARCOMA are mc in women who are ____

Answer 5

reproductive

postmenopausal

Question 6

inflam of the fallopian tubes caused by STI’s or from ectopic preg, endometriosis, tumor

Answer 6

salpingitis

Question 7

in fallopian tube carcinoma it is dx late and is usually an _____ with BRCA1 and 2 mutations

Answer 7

adenocarcinoma

Question 8

ovarian cysts are fairly normal and non problematic, and are caused by

Answer 8

ruptured follicles

Question 9

__ __ disease has multiple cystic follicles and ovaries can enlarge 2x in size

Answer 9

polycystic ovarian

Question 10

8th MC ca in US women, and 5th MC cause of ca-related death that include risk factors such as no or low pregnancies, fam hx of brca1/2, and >20yo

Answer 10

ovarian neoplasia

Question 11

ovarian neoplasia can invade various cell types but ___ ____ tumors represent 90% (benign or malig)

Answer 11

surface epi

Question 12

MC type of surface epi tumor

Answer 12

serous tumor

Question 13

__% of serous tumors are benign, ___% are malignant, and 95% have a TP53 mutation

Answer 13

60

25

Question 14

____ tumors are assoc with endometrial conditions, and are MC malignant, with 30% being bilateral

Answer 14

endometrioid

Question 15

placental infection/inflam are MC ___ infections that can be bacterial, or due to vaginal flora probs

Answer 15

ascending

Question 16

• disease of pregnancy with a non-uterine implantation that occurs in 1% of the population
• with acute ruptures in the 1st tri, fetus won’t dev

Answer 16

ectopic pregnancy

Question 17

__% of ectopic pregnancies are tubal, implanting in the fallopian tube

Answer 17

90

Question 18

• gest trophoblastic tumor that is large, swollen, BENIGN chorionic villi due to abnormal fertilization
• grape-like structure

Answer 18

hydatidiform mole

Question 19

gestational trophoblastic disease/tumor that is benign, INVASIVE, with no mets that can spontaneously regress

Answer 19

invasive mole

Question 20

aggressive malig of gestational chorionic epi that is usually dx late and shows extreme hCG and responds ~100% to chemo

Answer 20

choriocarcinoma

Question 21

if choriocarcinoma mets to the lungs, it is termed

Answer 21

cannon ball mets

Question 22

HTN, proteinuria, edema that occurs commonly with a first pregnancy, esp if mom is >35 yo

Answer 22

preeclampsia

Question 23

progression from preeclampsia that includes all of its symptoms + seizures and coma

Answer 23

eclampsia

Question 24

• intraepidural prolif of malig epi cells, located in breast or vulva, with no underlying tumor
• red scaly crusted plaque
• poor prog after mets

Answer 24

extramammary paget disease

Question 25

the presence of ___ separates extramammary paget disease from vulvar melanoma

Answer 25

mucin