ch 11 pt 3

Question 1

reduced ____ are seen in reticulocytopenia, aplastic crisis, and is caused by reduced erythropoiesis

Answer 1

reticulocytes

Question 2

____ anemias are caused by folic acid and vit b12 deficiencies

Answer 2

megaloblastic

Question 3

___ deficiency is the mc cause of anemia as 80% is in hb, and it is the mc nutritional deficiency
-reduces hemoglobin synthesis

Answer 3

iron

Question 4

in developing nations, iron def is caused by ____, while in devloped nations it is caused by ____
-rarely, increased metab demands such as preg/infancy

Answer 4

decreased intake

chronic blood loss

Question 5

two sources of chronic blood loss in developed countries, which leads to anemia

Answer 5

GI tract (ulcers, colon CA, hemorrhoids)
female genital tract

Question 6

iron def anemia is either asymp or mild, but presents with fatigue, impaired cognition, and ____

Answer 6

pica

Question 7

in megaloblastic anemia there is the prod of ____, with macrocytes that are macrocytic and hyperchromic

Answer 7

megaloblasts

Question 8

(3) demographic for rare folate deficiency anemia, which is insidious, causes fatigue and weakness

Answer 8

elderly
preg
alcoholism

Question 9

___ in peripheral blood and normal B12 are used to dx folate def anemia

Answer 9

macrocytes

Question 10

def anemia that disrupts maintenance of pns and sc, and is MC due to chronic malabs from mucosal atrophy MC in elderly

Answer 10

vit b12 (pernicious)

Question 11

a pt with fatigue, pallor, weakness, dyspnea, neuropathy, ataxia may have what type of anemia

Answer 11

vit b12 def

Question 12

neuro recover is unlikely with vit b12 def anemia, and a pt will have a subtle increased risk of ___ carcinoma

Answer 12

gastric

Question 13

anemia of chronic disease is MC among the ____, and has decreased erythropoiesis due to inflam - such as chronic/systemic inflam d/o

Answer 13

hospitalized

Question 14

three causes of anemia of chronic disease

Answer 14

microbial infections
immune d/o
neoplasia

Question 15

___ anemia is the suppression of myeloid stem cells and involves bone marrow failure
->1/2 are idiopathic, with a poor prog, via myelotoxic agents like adrs, toxins

Answer 15

aplastic

Question 16

aplastic anemia may have _____, which is decreased RBC, WBC, platelets

Answer 16

pancytopenia

Question 17

aplastic anemia can be caused by autoimmunity as seen in autoreactive ____, which attack bone marrow

Answer 17

t cells

Question 18

features of aplastic anemia are progressive, includes petechiae but ____ is characteristically absent

Answer 18

splenomegaly

Question 19

tx for aplastic anemia

Answer 19

immunosuppressive meds

Question 20

____ anemia has extensive infiltration of bone marrow, MC from mets to the bone (then breast, lung, prostate), also from chronic ____ disease such as tb

Answer 20

myelophthisic

granulomatous

Question 21

teardrop shaped rbc as seen in myelophthisic anemia

Answer 21

dacrocyte

Question 22

____ involves in increased concentration of rbcs and therefore increased hb

Answer 22

polycythemia

Question 23

___ polycythemia has decreased plasma, is from dehydration leading to hemoconcentration while ___ polycythemia has increased total RBC mass and is primarily a prolif of myeloid stem cells

Answer 23

relative

absolute

Question 24

secondary absolute polycythemia has increased serum ___ due to hypoxia or exogenous measures like blood doping

Answer 24

EPO